聚焦于口腔来源的干细胞中的 Hippo 通路、牙釉质形成和牙周组织再生。

State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.

Organogenesis. 2022 Dec 31;18(1):2082236. doi: 10.1080/15476278.2022.2082236.

Hippo pathway is a cellular regulatory pathway composed of core molecules such as MST1/2, LATS1/2, SAV1, MOB1A/B and downstream YAP/TAZ. Fully involved in regulating cell proliferation, differentiation, migration and apoptosis, the Hippo pathway is critical in regulating stem cells of oral origin, for instance, DPSCs and PDLSCs, enamel formation and periodontium regeneration. Here, we summarized the Hippo pathway involved in these progresses and concluded crosstalks of the Hippo pathway with BCL-2, ERK1/2, ROCK, TGF-β/BMP and Wnt/β-catenin pathways, hoping to provide foundation for further clinical therapy.

Hippo 通路是一个由核心分子（如 MST1/2、LATS1/2、SAV1、MOB1A/B 和下游的 YAP/TAZ）组成的细胞调节通路。它完全参与调节细胞增殖、分化、迁移和凋亡，在调节口腔来源的干细胞（例如 DPSCs 和 PDLSCs）、釉质形成和牙周组织再生方面起着关键作用。在这里，我们总结了 Hippo 通路在这些进展中所涉及的内容，并总结了 Hippo 通路与 BCL-2、ERK1/2、ROCK、TGF-β/BMP 和 Wnt/β-catenin 通路的相互作用，希望为进一步的临床治疗提供基础。