State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
J Cell Physiol. 2021 Nov;236(11):7792-7800. doi: 10.1002/jcp.30388. Epub 2021 Apr 12.
Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) are transcriptional coactivators encoded by paratactic homologous genes, shuttle-crossing between cytoplasm and nucleus to regulate the gene expression and cell behavior and standing at the center place of the sophisticated regulatory networking of mechanotransduction. Orthodontic tooth movement (OTM) is a process in which extracellular mechanical stimuli are transformed into intracellular biochemical signals to regulate cellular responses and tissue remodeling. Literature studies have confirmed that YAP/TAZ plays an important role not only in embryonic development, homeostasis and tumorigenesis, but also in mechanical-biochemical signal transduction of periodontal tissues under the mediation of various signal molecules in its upstream and downstream. Herein, we review the advances in the roles and mechanisms of YAP/TAZ in OTM to provide insights for better understanding and further study of the OTM and possible targeted clinical intervention in orthodontic treatment.
Yes 相关蛋白（YAP）和 PDZ 结合基序转录共激活因子（TAZ）是并列同源基因编码的转录共激活因子，在细胞质和细胞核之间穿梭，以调节基因表达和细胞行为，并处于机械转导复杂调控网络的中心位置。正畸牙齿移动（OTM）是一个过程，其中细胞外机械刺激被转化为细胞内生化信号，以调节细胞反应和组织重塑。文献研究证实，YAP/TAZ 不仅在胚胎发育、内稳态和肿瘤发生中发挥重要作用，而且在其上下游各种信号分子的介导下，在牙周组织的机械-生化信号转导中也发挥重要作用。本文综述了 YAP/TAZ 在 OTM 中的作用和机制的研究进展，为更好地理解和进一步研究 OTM 以及正畸治疗中可能的靶向临床干预提供了思路。
