Department of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
Texas Heart Institute, 6770 Bertner Avenue, Houston, TX 77030, USA.
Cardiovasc Res. 2022 Aug 24;118(11):2402-2414. doi: 10.1093/cvr/cvab291.
The Hippo pathway is an evolutionarily and functionally conserved signalling pathway that controls organ size by regulating cell proliferation, apoptosis, and differentiation. Emerging evidence has shown that the Hippo pathway plays critical roles in cardiac development, homeostasis, disease, and regeneration. Targeting the Hippo pathway has tremendous potential as a therapeutic strategy for treating intractable cardiovascular diseases, such as heart failure. In this review, we summarize the function of the Hippo pathway in the heart. Particularly, we highlight the post-translational modification of Hippo pathway components, including the core kinases LATS1/2 and their downstream effectors YAP/TAZ, in different contexts, which has provided new insights and avenues in cardiac research.
Hippo 通路是一条进化上和功能上保守的信号通路，通过调节细胞增殖、凋亡和分化来控制器官大小。新出现的证据表明，Hippo 通路在心脏发育、稳态、疾病和再生中发挥着关键作用。靶向 Hippo 通路作为治疗心力衰竭等难治性心血管疾病的治疗策略具有巨大的潜力。在这篇综述中，我们总结了 Hippo 通路在心脏中的功能。特别是，我们强调了 Hippo 通路成分的翻译后修饰，包括核心激酶 LATS1/2 及其下游效应物 YAP/TAZ，在不同的环境下，这为心脏研究提供了新的见解和途径。
