异常显著性与精神分裂症谱系障碍门诊患者的精神病维度相关。
Aberrant salience correlates with psychotic dimensions in outpatients with schizophrenia spectrum disorders.
作者信息
Pugliese Valentina, de Filippis Renato, Aloi Matteo, Rotella Paola, Carbone Elvira Anna, Gaetano Raffaele, De Fazio Pasquale
机构信息
Psychiatry Unit, Department of Health Sciences, University Magna Graecia of Catanzaro, Viale Europa, 88100, Catanzaro, Italy.
Department of Mental Health of Catanzaro, Lamezia Terme, Italy.
出版信息
Ann Gen Psychiatry. 2022 Jul 3;21(1):25. doi: 10.1186/s12991-022-00402-5.
BACKGROUND
Aberrant salience is a well-known construct associated with the development and maintenance of psychotic symptoms in schizophrenia. However, only a few studies have investigated aberrance salience as a trait, with no study investigating the association between the five aberrant salience domains and psychotic symptoms. We aimed to explore the role of aberrant salience and its domains on psychotic dimensions in both clinically remitted and non-remitted patients.
METHODS
A sample of 102 patients diagnosed with schizophrenia spectrum disorders was divided according to the Positive and Negative Syndrome Scale (PANSS) remission criteria into two groups: remitted and non-remitted. Differences regarding psychotic symptomatology assessed by the PANSS and aberrant salience measured by the Aberrant Salience Inventory (ASI) were explored. Finally, a correlation analysis between the PANSS and the ASI was run.
RESULTS
Significantly higher ASI scores were evident among non-remitted patients. Positive symptoms (i.e. delusions, conceptual disorganization, and hallucinatory behaviour) and general psychopathology (i.e. postural mannerisms, unusual thought content) were correlated to the aberrant salience subscales 'sharpening of senses', 'heightened emotionality' and 'heightened cognition' and with the ASI total score. Significant correlations emerged between negative symptoms (blunted affect and social withdrawal) and 'heightened cognition'. Finally, lack of spontaneity of conversation was related to the subscales 'heightened emotionality' and 'heightened cognition', as well as to the ASI total score.
CONCLUSIONS
These preliminary results support the hypothesis of an association between aberrant salience and psychotic symptoms in schizophrenia. Further research is needed, especially into the mechanisms underlying salience processing, in addition to social and environmental factors and cognitive variables.
背景
异常突显是一个与精神分裂症中精神病性症状的发展和维持相关的著名概念。然而，仅有少数研究将异常突显作为一种特质进行调查，尚无研究探究五个异常突显领域与精神病性症状之间的关联。我们旨在探讨异常突显及其领域在临床缓解和未缓解患者的精神病维度中的作用。
方法
根据阳性和阴性症状量表（PANSS）缓解标准，将102例被诊断为精神分裂症谱系障碍的患者样本分为两组：缓解组和未缓解组。探讨通过PANSS评估的精神病症状学差异以及通过异常突显量表（ASI）测量的异常突显差异。最后，对PANSS和ASI进行相关性分析。
结果
未缓解患者的ASI得分明显更高。阳性症状（即妄想、概念紊乱和幻觉行为）以及一般精神病理学（即姿势怪癖、异常思维内容）与异常突显子量表“感官敏锐化”、“情绪增强”和“认知增强”以及ASI总分相关。阴性症状（情感迟钝和社交退缩）与“认知增强”之间存在显著相关性。最后，对话缺乏自发性与子量表“情绪增强”和“认知增强”以及ASI总分相关。
结论
这些初步结果支持了精神分裂症中异常突显与精神病性症状之间存在关联的假设。除了社会和环境因素以及认知变量外，还需要进一步研究，特别是突显处理的潜在机制。
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