Gonzalez J G, Ghiselli R W, Santa Cruz D J
Am J Surg Pathol. 1987 May;11(5):343-50. doi: 10.1097/00000478-198705000-00002.
Synovial metaplasia has been described in bone or soft tissues following surgical procedures or under experimental conditions. Three cases in which skin biopsies showed synovial metaplasia of the dermis are herein reported. The metaplastic foci were associated with cyst formation and transepidermal fistulae. All patients had a history of previous surgical procedures in the area, and in all, the lesions clinically resembled suture granulomas. Microscopically, the lesions bore a striking resemblance to hyperplastic synovium. The immunohistochemical studies showed strong staining with vimentin and scattered positivity with alpha-1-antichymotrypsin (alpha-1ACT) and lysozyme. No basement membrane antigens or elastic fibers were demonstrated. We believe that the name "metaplastic synovial cyst" is an appropriate pathologic designation for this entity. An increased awareness of its occurrence will help to establish its true incidence.
滑膜化生已在手术操作后或实验条件下的骨或软组织中被描述。本文报告了3例皮肤活检显示真皮滑膜化生的病例。化生灶与囊肿形成和经表皮瘘有关。所有患者既往该区域均有手术史，且所有病变在临床上均类似缝线肉芽肿。显微镜下，病变与增生性滑膜极为相似。免疫组织化学研究显示波形蛋白呈强阳性染色，α-1抗糜蛋白酶（α-1ACT）和溶菌酶呈散在阳性。未显示基底膜抗原或弹性纤维。我们认为“化生滑膜囊肿”这一名称是该实体合适的病理诊断。提高对其发生的认识将有助于确定其真实发病率。
