Majdi Mina, Saffar Hana, Ghanadan Alireza
Dept. of Pathology, Cancer Institute, Imam Khomeini Hospital Complex, Tehran, Iran.
Dept. of Dermatopathology, Razi Skin Hospital, Tehran, Iran.
Iran J Pathol. 2016 Fall;11(5):423-426. Epub 2017 Jan 19.
Cutaneous metaplastic synovial cyst (CMSC), presents as a solitary, tender subcutaneous nodule that usually occurs at the site of previous surgery or trauma. Histologically, the lesion is characterized by a cystic structure with villous-like projections that lined by metaplastic synovial tissue. The main cause remains unclear, but trauma is presumed to be a precipitating factor, as most reported cases have a history of antecedent cutaneous injury. Here we present a case of CMSC in a 51 year old man, presented with a painless deep-seated dermal nodule in the medial aspect of left ankle without history of any trauma or surgery in this site. Immuno-histochemistry study reveals positive reaction for CD68 in the cystic wall and negative reactions for S-100. CMSC is a unique lesion and worthy to attention, and should be included in the differential diagnosis of deep dermal cutaneous cysts.
皮肤化生滑膜囊肿（CMSC）表现为单个、触痛的皮下结节，通常发生于既往手术或创伤部位。组织学上，病变的特征是具有囊性结构，伴有由化生滑膜组织衬里的绒毛样突起。主要病因尚不清楚，但据推测创伤是一个诱发因素，因为大多数报道的病例都有先前皮肤损伤史。在此，我们报告一例51岁男性的CMSC病例，其左踝内侧出现一个无痛的深部真皮结节，该部位无任何创伤或手术史。免疫组织化学研究显示囊肿壁CD68呈阳性反应，S-100呈阴性反应。CMSC是一种独特的病变，值得关注，应纳入深部真皮皮肤囊肿的鉴别诊断。
