补充 5,000 国际单位维生素 D 对妊娠期糖尿病妇女血糖谱的影响。
Effect of supplementation with 5,000 IU of vitamin D on the glycemic profile of women with gestational diabetes mellitus.
机构信息
Obstetrics Department, Hospital Civil de Guadalajara Dr. Juan I Menchaca, Guadalajara, Mexico.
Health Science Universitary Center, Universidad de Guadalajara, Guadalajara, Mexico.
出版信息
J Perinat Med. 2022 Jul 4;50(9):1225-1229. doi: 10.1515/jpm-2022-0096. Print 2022 Nov 25.
OBJECTIVES
The frequency of GDM and vitamin D insufficiency in Mexico is high. Vitamin D supplementation in GDM patients has shown favorable but non-homogeneous results regarding improvement of glycemic profile. The aim of the study was to assess the effects of supplementing with 5,000 IU of vitamin D on the glycemic profile of women with GDM.
METHODS
A randomized clinical trial was conducted on women with GDM who received 5,000 IU of vitamin D (n=27) or a placebo (n=27) for eight weeks. Changes in vitamin D levels and metabolic parameters before and after the intervention were analyzed.
RESULTS
Vitamin D vs. placebo: 25-OHD (32 vs. 26 ng/mL, p=0.006), HbA (6.0 vs. 6.1%, p=0.29), glucose (99 vs. 87 mg/dL, p=0.29), insulin (14 vs. 13 µIU/mL, p=0.79), HOMA-IR (3.6 vs. 2.6, p=0.55), QUICKI (0.31 vs. 0.33, p=0.55).
CONCLUSIONS
Supplementation with 5,000 IU of vitamin D for eight weeks had no significant effect on the glycemic profile.
目的
墨西哥的 GDM 和维生素 D 不足发生率很高。在 GDM 患者中补充维生素 D 已显示出改善血糖谱的有利但不一致的结果。本研究旨在评估补充 5,000IU 维生素 D 对 GDM 妇女血糖谱的影响。
方法
对接受 5,000IU 维生素 D（n=27）或安慰剂（n=27）治疗 8 周的 GDM 妇女进行随机临床试验。分析干预前后维生素 D 水平和代谢参数的变化。
结果
维生素 D 与安慰剂相比：25-OHD（32 与 26ng/mL，p=0.006）、HbA（6.0 与 6.1%，p=0.29）、血糖（99 与 87mg/dL，p=0.29）、胰岛素（14 与 13µIU/mL，p=0.79）、HOMA-IR（3.6 与 2.6，p=0.55）、QUICKI（0.31 与 0.33，p=0.55）。
结论
补充 5,000IU 维生素 D 8 周对血糖谱没有显著影响。
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