具有生物活性的吲哚里西啶生物碱。

Biologically active indolizidine alkaloids.

机构信息

School of Pharmacy, Lanzhou University, Lanzhou, China.

Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina, USA.

出版信息

Med Res Rev. 2021 Mar;41(2):928-960. doi: 10.1002/med.21747. Epub 2020 Oct 31.

DOI:10.1002/med.21747

PMID:33128409

Abstract

Indolizidine alkaloids are chemical constituents isolated from various marine and terrestrial plants and animals, including but not limited to trees, fungi, ants, and frogs, with a myriad of important biological activities. In this review, we discuss the biological activity and pharmacological effects of indolizidine alkaloids and offer new avenues toward the discovery of new and better drugs based on these naturally occurring compounds.

摘要

吲哚里西啶生物碱是从各种海洋和陆地动植物中分离出来的化学成分，包括但不限于树木、真菌、蚂蚁和青蛙，具有多种重要的生物活性。在这篇综述中，我们讨论了吲哚里西啶生物碱的生物活性和药理作用，并为基于这些天然化合物发现新的更好的药物提供了新的途径。