Bayraktar Bilen Neslihan, Bilen Sule
Department of Ophthalmology, Ankara Bilkent City Hospital, Ankara, Turkey.
Department of Neurology, Ankara Bilkent City Hospital, Ankara, Turkey.
Eur J Ophthalmol. 2023 Jan;33(1):216-222. doi: 10.1177/11206721221112518. Epub 2022 Jul 5.
To investigate the effect of eyelid spasm on corneal and tear film characteristics in patients with hemifacial spasm (HFS) and compare these data with those of the contralateral eyes of the same patients.
This prospective study is comprised of 64 eyes of 32 HFS patients, 32 eyes on the spasm side (Group 1) and 32 contralateral eyes (Group 2). Corneal tomographic analyses were performed; corneal power of flat axis (K1) and steep axis (K2), astigmatism and thinnest pachymetry; anterior, posterior and total corneal aberrometry [spherical aberration (SA), vertical coma (vcoma), horizontal coma (hcoma), total higher order aberration (THOA) and total RMS], and corneal densitometry values were evaluated and compared between groups. Tear meniscus height and depth (TMH, TMD) were measured using anterior segment optic coherence tomography. Tear function tests including TMH and TMD, the Schirmer I test, and tear break-up time (TBUT) were compared between the groups.
K1, K2, astigmatism and corneal densitometry values were similar between groups (p > 0.05). Thinnest pachymetry values were significantly thinner on the spasm side (p = 0.040). Anterior and total corneal SA and RMS were significantly higher on the spasm side (p = 0.032, p = 0.005; p = 0.015, p = 0.006, respectively). TMH, TMD and TBUT were significantly lower in Group 1 (p = 0.01, p = 0.02 and p = 0.03, respectively). Schirmer I test values were similar between groups (p > 0.05).
In HFS patients, there are changes in corneal parameters and tear film in the eye on the spasm side compared to unaffected eye.
研究眼睑痉挛对偏侧面肌痉挛（HFS）患者角膜和泪膜特征的影响，并将这些数据与同一患者对侧眼的数据进行比较。
这项前瞻性研究包括32例HFS患者的64只眼，痉挛侧32只眼（第1组）和对侧32只眼（第2组）。进行角膜断层分析；评估并比较两组之间的平轴角膜屈光力（K1）、陡轴角膜屈光力（K2）、散光和最薄角膜厚度；前、后和总角膜像差[球差（SA）、垂直彗差（vcoma）、水平彗差（hcoma）、总高阶像差（THOA）和总均方根误差（RMS）]以及角膜密度测量值。使用眼前节光学相干断层扫描测量泪河高度和深度（TMH、TMD）。比较两组之间包括TMH和TMD、泪液分泌试验和泪膜破裂时间（TBUT）在内的泪液功能测试。
两组之间的K1、K2、散光和角膜密度测量值相似（p＞0.05）。痉挛侧的最薄角膜厚度值明显更薄（p = 0.040）。痉挛侧的前角膜和总角膜SA及RMS明显更高（分别为p = 0.032，p = 0.005；p = 0.015，p = 0.006）。第1组的TMH、TMD和TBUT明显更低（分别为p = 0.01，p = 0.02和p = 0.03）。两组之间的泪液分泌试验值相似（p＞0.05）。
在HFS患者中，与未受影响的眼睛相比，痉挛侧眼睛的角膜参数和泪膜存在变化。
