[四川牦牛心包与澳大利亚牛心包的比较研究]
[Comparative study on Sichuan yak pericardium and Australian cattle pericardium].
作者信息
Zuo Yicong, Kang Ke, Shang Dapeng, Yang Xiayan, Wu Yao, Yu Qifeng, Wen Xiantao
机构信息
Chengdu NewMed Biotechnology Co., Ltd, Chengdu 611139, P. R. China.
Institute of Regulatory Science for Medical Device/College of Biomedical Engineering, Sichuan University, Chengdu 610065, P. R. China.
出版信息
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2022 Jun 25;39(3):537-543. doi: 10.7507/1001-5515.202202044.
Currently, as the key raw material of artificial biological heart valve, bovine pericardium is mainly depend on import and has become a "bottleneck" challenge, greatly limiting the development of domestic biological heart valve. Therefore, the localization of bovine pericardium is extremely urgent. In this study, the pericardium of Sichuan yak was compared with that of Australian cattle in terms of fundamental properties and anti-calcification performance. The results demonstrated that the appearance and thickness of yak pericardium were more advantageous than the Australian one. Sichuan yak pericardium and Australian cattle pericardium had comparable performance in shrinkage temperature, mechanical test and anti-calcification test. This study preliminarily verifies the feasibility of substitution of Australian cattle pericardium by Sichuan yak pericardium and promotes the progression of bovine pericardium localization with data support.
目前，牛心包作为人工生物心脏瓣膜的关键原材料，主要依赖进口，已成为“瓶颈”挑战，极大地限制了国内生物心脏瓣膜的发展。因此，牛心包的国产化迫在眉睫。本研究对四川牦牛心包与澳大利亚牛心包的基本性能和抗钙化性能进行了比较。结果表明，牦牛心包的外观和厚度比澳大利亚牛心包更具优势。四川牦牛心包与澳大利亚牛心包在收缩温度、力学测试和抗钙化测试方面表现相当。本研究初步验证了四川牦牛心包替代澳大利亚牛心包的可行性，并以数据支持推动了牛心包国产化的进程。
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