金属纳米颗粒作为一种有前途的靶向癌症治疗技术。

Department of Head and Neck Surgery, Otolaryngology & Head and Neck Center, Cancer Center, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou, China.

Key Laboratory of Endocrine Gland Diseases of Zhejiang Province, Hangzhou, China.

Drug Deliv. 2022 Dec;29(1):664-678. doi: 10.1080/10717544.2022.2039804.

Traditional anticancer treatments have several limitations, but cancer is still one of the deadliest diseases. As a result, new anticancer drugs are required for the treatment of cancer. The use of metal nanoparticles (NPs) as alternative chemotherapeutic drugs is on the rise in cancer research. Metal NPs have the potential for use in a wide range of applications. Natural or surface-induced anticancer effects can be found in metals. The focus of this review is on the therapeutic potential of metal-based NPs. The potential of various types of metal NPs for tumor targeting will be discussed for cancer treatment. The application of metal NPs for solid tumors will be reviewed. Risk factors involved in the clinical application of metal NPs will also be summarized.

传统的抗癌疗法有几个局限性，但癌症仍然是最致命的疾病之一。因此，需要新的抗癌药物来治疗癌症。金属纳米粒子（NPs）作为替代化疗药物在癌症研究中越来越受到关注。金属 NPs 具有广泛应用的潜力。金属中存在天然或表面诱导的抗癌作用。本综述的重点是基于金属的 NPs 的治疗潜力。将讨论各种类型的金属 NPs 对肿瘤靶向治疗癌症的潜力。综述了金属 NPs 在实体瘤中的应用。还将总结金属 NPs 临床应用中涉及的风险因素。