Department of Pharmacognosy, School of Pharmacy, Istanbul Medipol University, Beykoz, Istanbul, Turkey.
Graduate School of Health Sciences, Anadolu University, Eskişehir, Turkey.
Planta Med. 2023 Jul;89(8):800-807. doi: 10.1055/a-1891-1119. Epub 2022 Jul 4.
Microbial resistance is an important problem in modern healthcare systems. In addition to drug resistance, the side effects of current antibiotic applications are also known issues. In this present study, binary combinations of amoxicillin with European Pharmacopoeia quality lavender () and fennel () essential oils were evaluated against human pathogenic microbial strains. The checkerboard method was used to quantify the efficacy of the essential oils in combination with amoxicillin. As an initial result, remarkable antimicrobial activity was observed at relatively low amoxicillin concentrations using different oil combinations against ATCC 6538, ATCC 29212, ATCC 14579, NRRL B-3008, (clinical isolate), respectively. Fractional inhibitory concentrations were calculated and interpreted in terms of addition, synergy, antagonism, or indifferent. A synergistic interaction with the combination essential oil and amoxicillin (fractional inhibitory concentration index = 8.05 × 10) was observed against the pathogens and . Both essential oils together and in combination with amoxicillin showed a synergistic effect with possible future applications.
微生物耐药性是现代医疗体系中的一个重要问题。除了耐药性，当前抗生素应用的副作用也是已知的问题。在本研究中，评估了阿莫西林与欧洲药典质量薰衣草（ ）和茴香（ ）精油的二元组合对人体致病微生物菌株的作用。棋盘法用于量化精油与阿莫西林联合使用的效果。初步结果表明，使用不同的油组合，在相对较低的阿莫西林浓度下，对 ATCC 6538、 ATCC 29212、 ATCC 14579、 NRRL B-3008 和（临床分离株）表现出显著的抗菌活性。计算并解释了部分抑菌浓度，以表示相加、协同、拮抗或无关。与阿莫西林（抑菌浓度指数= 8.05×10）组合的精油表现出协同相互作用。两种精油一起以及与阿莫西林联合使用均表现出协同作用，可能具有未来的应用前景。
