Guyatt G H, Townsend M, Pugsley S O, Keller J L, Short H D, Taylor D W, Newhouse M T
Am Rev Respir Dis. 1987 May;135(5):1069-74. doi: 10.1164/arrd.1987.135.5.1069.
We conducted a trial of inhaled salbutamol and orally administered theophylline in patients whose acute response to inhaled salbutamol was less than 25% of their baseline FEV1. Patients underwent 4 treatment periods, each of 2 wk duration, during which they received the following combinations: placebo-placebo, placebo-salbutamol, placebo-theophylline, and salbutamol-theophylline. The 19 patient who completed the study were all males with a mean age of 65 +/- 7.4 yr, mean FEV1 of 1.02 +/- 0.38, and mean VC of 2.73 +/- 0.19. Outcomes included twice-daily recordings of peak flow rates, spirometry, the distance patients could walk in 6 min, and clinical symptoms of dyspnea, fatigue, and emotional function. Clinically important and statistically significant differences between the 4 periods were noted on both physiologic and functional outcomes. For the group as a whole, improvement with inhaled salbutamol and orally administered theophylline was comparable, and additional benefit was gained from a combination of the 2 drugs. We conclude that both inhaled salbutamol and orally administered theophylline can improve airflow obstruction, functional exercise capacity, and quality of life in patients with primarily fixed air-flow limitation.
我们对吸入沙丁胺醇和口服氨茶碱进行了一项试验，试验对象为对吸入沙丁胺醇的急性反应小于其基线第一秒用力呼气量（FEV1）25%的患者。患者经历了4个治疗期，每个治疗期持续2周，在此期间他们接受以下组合治疗：安慰剂-安慰剂、安慰剂-沙丁胺醇、安慰剂-氨茶碱以及沙丁胺醇-氨茶碱。完成研究的19名患者均为男性，平均年龄为65±7.4岁，平均FEV1为1.02±0.38，平均肺活量（VC）为2.73±0.19。观察指标包括每日两次记录的峰值流速、肺功能测定、患者6分钟内行走的距离以及呼吸困难、疲劳和情绪功能的临床症状。在生理和功能指标方面，4个治疗期之间均存在具有临床意义且具有统计学显著性的差异。对于整个研究组而言，吸入沙丁胺醇和口服氨茶碱的改善效果相当，两种药物联合使用可带来额外益处。我们得出结论，吸入沙丁胺醇和口服氨茶碱均可改善主要存在固定气流受限患者的气流阻塞、功能运动能力和生活质量。
