Department of Food Science and Technology, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.
Nebraska Food for Health Center, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.
BMJ Open Gastroenterol. 2022 Jul;9(1). doi: 10.1136/bmjgast-2022-000906.
The effects of food sensitivity can easily be masked by other digestive symptoms in ostomates and are unknown. We investigated food-specific-IgG presence in ostomates relative to participants affected by other digestive diseases.
Food-specific-IgG was evaluated for 198 participants with a panel of 109 foods. Immunocompetency status was also tested. Jejunostomates, ileostomates and colostomates were compared with individuals with digestive tract diseases with inflammatory components (periodontitis, eosinophilic esophagitis, duodenitis, ulcerative colitis, Crohn's disease and appendicitis), as well as food malabsorption due to intolerance. A logistic regression model with covariates was used to estimate the effect of the experimental data and demographic characteristics on the likelihood of the immune response.
Jejunostomates and ileostomates had a significant risk of presenting circulating food-specific-IgG in contrast to colostomates (OR 12.70 (p=0.002), 6.19 (p=0.011) and 2.69 (p=0.22), respectively). Crohn's disease, eosinophilic esophagitis and food malabsorption groups also showed significantly elevated risks (OR 4.67 (p=0.048), 8.16 (p=0.016) and 18.00 (p=0.003), respectively), but not the ulcerative colitis group (OR 2.05 (p=0.36)). Individuals with profoundly or significantly reduced, and mild to moderately reduced, levels of total IgG were protected from the formation of food-specific IgG (OR 0.09 (p=<0.001) and 0.33 (p=0.005), respectively). Males were at higher risk than females.
The strength of a subject's immunocompetence plays a role in the intensity to which the humoral system responds via food-specific-IgG. An element of biogeography emerges in which the maintenance of a colonic space might influence the risk of having circulating food-specific-IgG in ostomates.
食物敏感性的影响很容易被造口患者的其他消化症状所掩盖，目前尚不清楚。我们调查了造口患者中食物特异性 IgG 的存在情况，并与患有其他消化道疾病的参与者进行了比较。
我们用 109 种食物的面板评估了 198 名参与者的食物特异性 IgG。同时还测试了免疫功能状态。比较了空肠造口、回肠造口和结肠造口与具有炎症成分的消化道疾病患者（牙周炎、嗜酸性食管炎、十二指肠炎、溃疡性结肠炎、克罗恩病和阑尾炎），以及由于不耐受导致的食物吸收不良的患者。使用带有协变量的逻辑回归模型来估计实验数据和人口统计学特征对免疫反应可能性的影响。
与结肠造口患者相比，空肠造口和回肠造口患者具有显著更高的循环食物特异性 IgG 的风险（OR 12.70（p=0.002）、6.19（p=0.011）和 2.69（p=0.22））。克罗恩病、嗜酸性食管炎和食物吸收不良组也显示出显著更高的风险（OR 4.67（p=0.048）、8.16（p=0.016）和 18.00（p=0.003）），但溃疡性结肠炎组则没有（OR 2.05（p=0.36））。总 IgG 水平严重或显著降低以及轻度至中度降低的个体，其食物特异性 IgG 的形成受到保护（OR 0.09（p=<0.001）和 0.33（p=0.005））。男性比女性的风险更高。
个体免疫能力的强弱在通过食物特异性 IgG 进行体液系统反应的强度方面起着作用。在造口患者中，一种生物地理学的元素出现了，即结肠空间的维持可能会影响循环食物特异性 IgG 的风险。
