Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran.
Department of Ophthalmology, Khatam Ol-Anbia Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
Neurochem Res. 2022 Oct;47(10):2936-2953. doi: 10.1007/s11064-022-03666-1. Epub 2022 Jul 5.
Gliomas are common and aggressive brain tumors that carry a poor prognosis. The current multimodal therapeutic option for glioma includes surgery subsequently temozolomide chemotherapy and/or radiation; but gliomas are often associated with multidrug resistance, intensive adverse events, and tumor relapse. Thus, novel interventions that can enhance successful chemo-prevention and overcome therapeutic resistance are urgently needed. Phytochemicals have several biological properties with multi-target sites and relatively limited degrees of toxicity. Curcumin is a natural polyphenolic compound with several anti-tumor effects which potentially inhibit tumor growth, development, proliferation, invasion, dissemination, and angiogenesis in different human malignancies. Experimental model studies have demonstrated that curcumin attenuates glioma cell viability by G2/M cell cycle arrest, apoptosis, induction of autophagy, gene expression alteration, and disruption of multi-molecular pathways. Moreover, curcumin has been reported to re-sensitize cancer to chemotherapeutics as well as augment the effect of radiotherapy on glioma cells. In this review, we have provided an update on the in vitro and in vivo effects of curcumin-based therapy on gliomas. We have also discussed the use of curcumin in combination therapies, its effectiveness on drug-resistant cells, and new formulations of curcumin in the treatment of gliomas.
神经胶质瘤是常见且侵袭性的脑肿瘤，预后不良。目前，神经胶质瘤的多模态治疗选择包括手术，随后是替莫唑胺化疗和/或放疗；但神经胶质瘤常伴有多药耐药、严重不良反应和肿瘤复发。因此，迫切需要新的干预措施，以增强成功的化疗预防并克服治疗耐药性。植物化学物质具有多种生物特性，靶点多，毒性相对有限。姜黄素是一种天然多酚化合物，具有多种抗肿瘤作用，可潜在抑制不同人类恶性肿瘤的肿瘤生长、发展、增殖、侵袭、扩散和血管生成。实验模型研究表明，姜黄素通过 G2/M 细胞周期阻滞、细胞凋亡、自噬诱导、基因表达改变和破坏多分子途径来减弱神经胶质瘤细胞活力。此外，据报道，姜黄素可使癌细胞重新对化疗药物敏感，并增强放疗对神经胶质瘤细胞的作用。在这篇综述中，我们提供了关于姜黄素为基础的治疗对神经胶质瘤的体外和体内作用的最新信息。我们还讨论了姜黄素联合治疗的应用、其对耐药细胞的有效性以及姜黄素在治疗神经胶质瘤方面的新配方。
