Leybovitz-Haleluya Noa, Sheiner Eyal, Pariente Gali, Wainstock Tamar
Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
The Department of Public Health, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
J Perinatol. 2022 Dec;42(12):1587-1591. doi: 10.1038/s41372-022-01448-9. Epub 2022 Jul 5.
We aimed to study the association between fetal gender in twin pregnancies and the risk for childhood infectious morbidity of the offspring.
A population-based cohort analysis was performed comparing total and subtypes of infectious related pediatric hospitalizations among males versus females offspring of twin pregnancies. The analysis included all dichorionic twins born between the years 1991-2021. A Kaplan-Meier survival curve was used to compare the cumulative infectious morbidity incidence, and a Cox proportional hazards model was constructed to adjust for confounders.
The study population included 4222 newborns (2111 males and 2111 females). Males had higher rates of infectious-related hospitalizations using a Cox proportional hazards model, an independent association was shown between male gender and infectious related hospitalizations of the offspring (Adjusted HR = 1.2, 95% CI: 1.1-1.4; p < 0.001).
Male gender in twin pregnancies is associated with an increased risk for long-term pediatric infectious morbidity.
我们旨在研究双胎妊娠中胎儿性别与后代儿童期感染性疾病发病风险之间的关联。
进行了一项基于人群的队列分析，比较双胎妊娠男性与女性后代中与感染相关的儿科住院总数及亚型。该分析纳入了1991年至2021年间出生的所有双绒毛膜双胎。采用Kaplan-Meier生存曲线比较累积感染性疾病发病率，并构建Cox比例风险模型以调整混杂因素。
研究人群包括4222名新生儿（2111名男性和2111名女性）。使用Cox比例风险模型时，男性与感染相关的住院率更高，男性性别与后代感染相关住院之间存在独立关联（调整后风险比=1.2，95%置信区间：1.1-1.4；p<0.001）。
双胎妊娠中的男性胎儿与儿童期长期感染性疾病发病风险增加有关。
