Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
Department of Pharmacology, Faculty of Medicine and Defence Health, Universiti Pertahanan Nasional Malaysia, Kuala Lumpur, Malaysia.
Pak J Pharm Sci. 2022 May;35(3):747-753.
Addition of citrus leaf extract (CLE) into frying oil was found to be renoprotective in rats that consumed heated palm oil diet. This study examined the effects of dietary CLE supplementation on renal vasoactive substances in rats given heated palm oil diet. Forty-two male Sprague-Dawley rats were randomly split and fed with (i) control, (ii) fresh palm oil (FPO), (iii) FPO + CLE, (iv) five-time-heated palm oil (5HPO), (v) 5HPO+CLE, (vii) ten-time-heated palm oil (10HPO) and (vii) 10HPO+CLE diets for 16 weeks. CLE was added into diet at 0.15% (w/w). CLE decreased renal angiotensin-converting enzyme, inducible nitric oxide synthase and angiotensin II expressions in rats given heated oil diets, but only decreased renal NADPH oxidase activity in the 5HPO group. Supplementation of citrus leaf extract has shown beneficial effects in regulating renal vasoactive substances in rats consumed heated palm oil diet.
在摄入加热棕榈油饮食的大鼠中，添加柑橘叶提取物（CLE）到食用油中被发现具有肾脏保护作用。本研究旨在探讨膳食 CLE 补充对给予加热棕榈油饮食的大鼠肾脏血管活性物质的影响。42 只雄性 Sprague-Dawley 大鼠随机分为 7 组，分别给予（i）对照、（ii）新鲜棕榈油（FPO）、（iii）FPO+CLE、（iv）五次加热棕榈油（5HPO）、（v）5HPO+CLE、（vi）十次加热棕榈油（10HPO）和（vii）10HPO+CLE 饮食，持续 16 周。CLE 以 0.15%（w/w）添加到饮食中。CLE 降低了摄入加热油饮食大鼠的肾脏血管紧张素转换酶、诱导型一氧化氮合酶和血管紧张素 II 的表达，但仅降低了 5HPO 组的肾脏 NADPH 氧化酶活性。柑橘叶提取物的补充对调节摄入加热棕榈油饮食的大鼠肾脏血管活性物质具有有益作用。
