Faculty of Medicine, Department of Infectious Diseases, 277693University Ferhat Abbas Setif 1, Algeria.
Faculty of Medicine, Department of epidemiology and preventive medicine, 389767University of Constantine 3, Algeria.
Trop Doct. 2022 Oct;52(4):479-483. doi: 10.1177/00494755221112212. Epub 2022 Jul 6.
Hepatitis E virus (HEV) is recognized worldwide as the leading cause of orofecal-transmitted hepatitis. However, blood transmission has been increasingly implicated in recent years raising health concerns. In Algeria, updated prevalence data are lacking. We aimed to determine the prevalence of anti-HEV antibodies in the sera of volunteer blood donors from the Setif region in eastern Algeria. A total of 434 Samples were analyzed for anti-HEV IgG and IgM antibodies using an enzyme-linked immunosorbent assay (Wantai). Logistic regression modelling was used to identify associated risk factors. The IgG seroprevalence rate was 17.05%. Seven sera (0.16%) were weakly positive for IgM. No HEV RNA was detected. The IgG prevalence was significantly correlated with increasing age (p < 1p.1000). Our data demonstrate a relatively high prevalence of anti-HEV IgG, indicating a possible risk of HEV blood transmission which requires vireamic seroprevalence studies to assess the real risk.
戊型肝炎病毒（HEV）已被全球公认为经口-粪传播的肝炎的主要病因。然而，近年来血液传播的情况越来越多，引起了人们对健康的关注。在阿尔及利亚，缺乏最新的流行数据。本研究旨在确定阿尔及利亚东部塞提夫地区志愿献血者血清中抗-HEV 抗体的流行率。使用酶联免疫吸附试验（万泰）分析了总共 434 份样本的抗-HEV IgG 和 IgM 抗体。采用逻辑回归模型确定相关的危险因素。IgG 血清阳性率为 17.05%。7 份血清（0.16%）的 IgM 呈弱阳性。未检测到 HEV RNA。IgG 流行率与年龄增加显著相关（p<0.001）。我们的数据表明抗-HEV IgG 的流行率相对较高，表明可能存在 HEV 血液传播的风险，需要进行病毒血症血清流行率研究来评估真实的风险。
