Eslamian Ghazaleh, Sali Sohrab, Babaei Mansour, Parastouei Karim, Moghadam Dorsa Arman
Department of Cellular and Molecular Nutrition, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Health Research Center, Life Style Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Acute Crit Care. 2022 Aug;37(3):332-338. doi: 10.4266/acc.2021.01830. Epub 2022 Jul 5.
Malnutrition affects normal body function and is associated with disease severity and mortality. Due to the high prevalence of malnutrition reported in patients with coronavirus disease 2019 (COVID-19), the current study examined the association between malnutrition and disease severity in hospitalized adult patients with COVID-19 in Iran.
In this prospective observational study, 203 adult patients with COVID-19 verified by real-time polymerase chain reaction test and chest computed tomography were recruited from those admitted to a university hospital in Iran. To determine COVID-19 intensity, patients were categorized into four groups. Malnutrition assessment was based on the Malnutrition Universal Screening Tool (MUST) and nutrition risk screening score (NRS-2002). An ordinal regression model was run to assess the association between malnutrition and disease severity.
In the studies sample of Iranian patients with COVID-19, 38.3% of patients had severe COVID-19. According to NRS-2002, 12.9% of patients were malnourished. Based on MUST, 2% of patients were at medium, and 13.4% of patients were at high risk of malnutrition. Malnutrition was associated with a higher odds of extremely severe COVID-19 according to NRS-2002 (odds ratio, 1.38; 95% confidence interval, 0.21-2.56; P=0.021).
Malnutrition was not prevalent in the studies sample of Iranian patients with COVID-19; however, it was associated with a higher odds of extremely severe COVID-19.
营养不良会影响身体正常功能，并与疾病严重程度和死亡率相关。由于2019冠状病毒病（COVID-19）患者中报告的营养不良患病率较高，本研究调查了伊朗住院成年COVID-19患者中营养不良与疾病严重程度之间的关联。
在这项前瞻性观察研究中，从伊朗一家大学医院收治的患者中招募了203名经实时聚合酶链反应检测和胸部计算机断层扫描确诊的成年COVID-19患者。为了确定COVID-19的严重程度，将患者分为四组。营养不良评估基于营养不良通用筛查工具（MUST）和营养风险筛查评分（NRS-2002）。运行有序回归模型以评估营养不良与疾病严重程度之间的关联。
在伊朗COVID-19患者的研究样本中，38.3%的患者患有严重COVID-19。根据NRS-2002，12.9%的患者营养不良。根据MUST，2%的患者处于中度营养不良风险，13.4%的患者处于高度营养不良风险。根据NRS-2002，营养不良与极重度COVID-19的较高几率相关（比值比，1.38；95%置信区间，0.21-2.56；P=0.021）。
在伊朗COVID-19患者的研究样本中，营养不良并不普遍；然而，它与极重度COVID-19的较高几率相关。
