Department of Cardiology, Gazi Yaşargil Training and Research Hospital, Diyarbakır, Turkey.
Department of Physical Therapy and Rehabilitation, Gazi Yaşargil Training and Research Hospital, Diyarbakır, Turkey.
Anatol J Cardiol. 2022 Jul;26(7):525-531. doi: 10.5152/AnatolJCardiol.2022.907.
Facioscapulohumeral muscular dystrophy is one of the most common congenital muscle disorders. Whether facioscapulohumeral muscular dystrophy causes cardiac involvement is still controversial. Although electrocardiography and conventional echocardiography studies have been performed, there is no data on strain echocardiography in facioscapulohumeral muscular dystrophy. Our study aims to compare the myocardial strain parameters by 2-dimensional speckle tracking echocardiography in patients with facioscapulohumeral muscular dystrophy and the normal group.
This prospective single-center study included 35 patients with facioscapulohumeral muscular dystrophy and 54 control patients. Demographic, clinical, and laboratory parameters of both groups were compared. In addition to conventional echocardiography images, myocardial strain parameters were performed using 2-dimensional speckle tracking echocardiography.
The median age of the study population was 25 (19-35 IQR) and 51 (57.3%) of them were male. Left ventricle-global circumferential strain was significantly lower in the facioscapulohumeral muscular dystrophy group than in the normal group [−20.3 (−22.0; −19.0) vs. −21.6 (−22.5; −20.0), P = .020]. Two-dimensional speckle tracking echocardiography findings except left ventricle-global circumferential strain [for left ventricle-global longitudinal strain P = .259, for left ventricle-global radial strain P = .338, for right ventricle-global circumferential strain P=.250, and for right ventricle-free wall longitudinal strain P = .288] were similar in both groups.
As a result of our study, there was no significant difference between 2-dimensional speckle tracking echocardiography parameters other than the left ventricle-global circumferential strain between facioscapulohumeral muscular dystrophy and normal groups.
面肩肱型肌营养不良症是最常见的先天性肌肉疾病之一。面肩肱型肌营养不良症是否引起心脏受累仍存在争议。尽管已经进行了心电图和常规超声心动图研究，但在面肩肱型肌营养不良症中尚无应变超声心动图的数据。我们的研究旨在比较面肩肱型肌营养不良症患者和正常组的二维斑点追踪超声心动图的心肌应变参数。
这是一项前瞻性单中心研究，纳入了 35 名面肩肱型肌营养不良症患者和 54 名对照组患者。比较了两组的人口统计学、临床和实验室参数。除了常规超声心动图图像外，还使用二维斑点追踪超声心动图测量心肌应变参数。
研究人群的中位数年龄为 25 岁（19-35 IQR），其中 51 名（57.3%）为男性。面肩肱型肌营养不良症组的左心室整体周向应变明显低于正常组[−20.3（−22.0；−19.0）比−21.6（−22.5；−20.0），P=.020]。二维斑点追踪超声心动图的发现除了左心室整体周向应变[左心室整体纵向应变的 P=.259，左心室整体径向应变的 P=.338，右心室整体周向应变的 P=.250，右心室游离壁纵向应变的 P=.288]在两组之间相似。
由于我们的研究，面肩肱型肌营养不良症组和正常组之间除了左心室整体周向应变之外，二维斑点追踪超声心动图参数没有显著差异。
