INSERM U1254, Université de Lorraine, IADI, 54000 Nancy, France; BioSerenity, 20 Rue Berbier du Mets, 75013 Paris, France.
CRAN, CNRS UMR 7039, Université de Lorraine, 54000 Nancy, France.
Neurosci Biobehav Rev. 2022 Sep;140:104764. doi: 10.1016/j.neubiorev.2022.104764. Epub 2022 Jul 2.
Bipolar disorder is a lifelong condition. Today, there is a urgent need to find indicators of the disease. Specifically, they could be useful to improve the diagnosis and the early detection, the prognosis, to estimate the treatment response and to create homogeneous subgroups of patients based on similar pathophysiological mechanisms. Here, we assume that visual electrophysiology in combination with a neuropsychological assessment can give additional data to routine practice, especially to precise specific damages and pathophysiological characteristics of these patients. Visual electrophysiology is characterized by an electroretinogram and the delivery of visual evoked potentials, which measure retinal and visual cortical neuronal functioning in response to visual stimulations. This review highlights the interest of visual electrophysiology and neuropsychology performed in isolation and to present the benefits of combining these measures. We will review the results based on these measures in patients with bipolar disorders. Finally, we argue for the use of innovative techniques such as signal processing and artificial intelligence techniques for routine care and precision medicine in bipolar disorders.
双相情感障碍是一种终身疾病。如今，迫切需要找到该疾病的指标。具体来说，这些指标可以有助于改善诊断和早期发现、预后、评估治疗反应，并根据相似的病理生理机制创建同质的患者亚组。在这里，我们假设视觉电生理学结合神经心理学评估可以提供常规实践之外的附加数据，特别是可以精确确定这些患者的具体损伤和病理生理特征。视觉电生理学的特征在于视网膜电图和视觉诱发电位的传递，这些可以测量视网膜和视觉皮质神经元对视觉刺激的反应功能。本综述重点介绍了单独进行视觉电生理学和神经心理学检查的意义，并介绍了结合这些检查的益处。我们将根据双相情感障碍患者的这些检查结果进行综述。最后，我们主张在双相情感障碍的常规护理和精准医疗中使用信号处理和人工智能等创新技术。
