Flashfm-ivis：用于多个数量性状精细定位的交互式可视化工具。

Flashfm-ivis: interactive visualization for fine-mapping of multiple quantitative traits.

机构信息

MRC Biostatistics Unit, University of Cambridge, Cambridge CB2 0SR, UK.

British Heart Foundation, Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.

出版信息

Bioinformatics. 2022 Sep 2;38(17):4238-4242. doi: 10.1093/bioinformatics/btac453.

DOI:10.1093/bioinformatics/btac453

PMID:35792838

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9438951/

Abstract

SUMMARY

flashfm-ivis provides a suite of interactive visualization plots to view potential causal genetic variants that underlie associations that are shared or distinct between multiple quantitative traits and compares results between single- and multi-trait fine-mapping. Unique features include network diagrams that show joint effects between variants for each trait and regional association plots that integrate fine-mapping results, all with user-controlled zoom features for an interactive exploration of potential causal variants across traits.

AVAILABILITY AND IMPLEMENTATION

flashfm-ivis is an open-source software under the MIT license. It is available as an interactive web-based tool (http://shiny.mrc-bsu.cam.ac.uk/apps/flashfm-ivis/) and as an R package. Code and documentation are available at https://github.com/fz-cambridge/flashfm-ivis and https://zenodo.org/record/6376244#.YjnarC-l2X0. Additional features can be downloaded as standalone R libraries to encourage reuse.

SUPPLEMENTARY INFORMATION

Supplementary information are available at Bioinformatics online.

摘要

flashfm-ivis 提供了一系列交互式可视化图形，用于查看潜在的因果遗传变异，这些变异是多个定量性状之间共享或独特的关联的基础，并比较单性状和多性状精细映射之间的结果。独特的功能包括显示每个性状的变异之间联合效应的网络图，以及整合精细映射结果的区域关联图，所有这些都具有用户控制的缩放功能，可在跨性状的潜在因果变异之间进行交互式探索。