• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

在 125000 名非洲裔个体中进行多特征发现和脂质基因座的精细定位。

Multi-trait discovery and fine-mapping of lipid loci in 125,000 individuals of African ancestry.

机构信息

The African Computational Genomic (TACG) Research Group, MRC/UVRI and LSHTM, Entebbe, Uganda.

Malawi Epidemiology and Intervention Research Unit, Lilongwe, Malawi.

出版信息

Nat Commun. 2023 Sep 5;14(1):5403. doi: 10.1038/s41467-023-41271-0.

DOI:10.1038/s41467-023-41271-0
PMID:37669986
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10480211/
Abstract

Most genome-wide association studies (GWAS) for lipid traits focus on the separate analysis of lipid traits. Moreover, there are limited GWASs evaluating the genetic variants associated with multiple lipid traits in African ancestry. To further identify and localize loci with pleiotropic effects on lipid traits, we conducted a genome-wide meta-analysis, multi-trait analysis of GWAS (MTAG), and multi-trait fine-mapping (flashfm) in 125,000 individuals of African ancestry. Our meta-analysis and MTAG identified four and 14 novel loci associated with lipid traits, respectively. flashfm yielded an 18% mean reduction in the 99% credible set size compared to single-trait fine-mapping with JAM. Moreover, we identified more genetic variants with a posterior probability of causality >0.9 with flashfm than with JAM. In conclusion, we identified additional novel loci associated with lipid traits, and flashfm reduced the 99% credible set size to identify causal genetic variants associated with multiple lipid traits in African ancestry.

摘要

大多数脂质特征的全基因组关联研究（GWAS）都侧重于对脂质特征的单独分析。此外，评估非洲血统人群中与多种脂质特征相关的遗传变异的 GWAS 非常有限。为了进一步鉴定和定位对脂质特征具有多效性影响的基因座，我们在 125000 名非洲血统个体中进行了全基因组荟萃分析、GWAS 的多特征分析（MTAG）和多特征精细映射（flashfm）。我们的荟萃分析和 MTAG 分别确定了四个和 14 个与脂质特征相关的新基因座。与单特征精细映射的 JAM 相比，flashfm 使 99%可信区间的平均大小减少了 18%。此外，与 JAM 相比，我们用 flashfm 鉴定出了更多具有因果关系后验概率>0.9 的遗传变异。总之，我们发现了与脂质特征相关的更多新基因座，并且 flashfm 缩小了 99%的可信区间大小，以鉴定与非洲血统多种脂质特征相关的因果遗传变异。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d13b/10480211/98973f09d4e2/41467_2023_41271_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d13b/10480211/c557150a4c96/41467_2023_41271_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d13b/10480211/4c1ac9861368/41467_2023_41271_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d13b/10480211/98973f09d4e2/41467_2023_41271_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d13b/10480211/c557150a4c96/41467_2023_41271_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d13b/10480211/4c1ac9861368/41467_2023_41271_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d13b/10480211/98973f09d4e2/41467_2023_41271_Fig3_HTML.jpg

相似文献

1
Multi-trait discovery and fine-mapping of lipid loci in 125,000 individuals of African ancestry.在 125000 名非洲裔个体中进行多特征发现和脂质基因座的精细定位。
Nat Commun. 2023 Sep 5;14(1):5403. doi: 10.1038/s41467-023-41271-0.
2
The flashfm approach for fine-mapping multiple quantitative traits.快速映射多点定量性状的 flashfm 方法。
Nat Commun. 2021 Oct 22;12(1):6147. doi: 10.1038/s41467-021-26364-y.
3
Discovery and fine-mapping of adiposity loci using high density imputation of genome-wide association studies in individuals of African ancestry: African Ancestry Anthropometry Genetics Consortium.利用非洲裔个体全基因组关联研究的高密度归因法发现肥胖位点并进行精细定位：非洲裔人体测量学遗传学联盟
PLoS Genet. 2017 Apr 21;13(4):e1006719. doi: 10.1371/journal.pgen.1006719. eCollection 2017 Apr.
4
Discovery and fine-mapping of height loci via high-density imputation of GWASs in individuals of African ancestry.通过对非裔个体全基因组关联研究的高密度插补发现和精细定位身高位点。
Am J Hum Genet. 2021 Apr 1;108(4):564-582. doi: 10.1016/j.ajhg.2021.02.011. Epub 2021 Mar 12.
5
Identifying genetic loci and phenomic associations of substance use traits: A multi-trait analysis of GWAS (MTAG) study.鉴定物质使用特征的遗传基因座和表型关联：全基因组关联研究的多性状分析（MTAG）研究。
Addiction. 2023 Oct;118(10):1942-1952. doi: 10.1111/add.16229. Epub 2023 May 22.
6
Multi-trait genome-wide association analyses leveraging alcohol use disorder findings identify novel loci for smoking behaviors in the Million Veteran Program.利用酒精使用障碍研究结果进行的多特征全基因组关联分析，在百万退伍军人计划中为吸烟行为确定了新的基因座。
Transl Psychiatry. 2023 May 5;13(1):148. doi: 10.1038/s41398-023-02409-2.
7
Genome-wide association study in individuals of European and African ancestry and multi-trait analysis of opioid use disorder identifies 19 independent genome-wide significant risk loci.全基因组关联研究在欧洲和非洲血统个体中进行，以及阿片类药物使用障碍的多特征分析确定了 19 个独立的全基因组显著风险位点。
Mol Psychiatry. 2022 Oct;27(10):3970-3979. doi: 10.1038/s41380-022-01709-1. Epub 2022 Jul 25.
8
Comparison of two multi-trait association testing methods and sequence-based fine mapping of six additive QTL in Swiss Large White pigs.比较两种多性状关联测试方法和瑞士大白猪六个加性 QTL 的基于序列的精细定位。
BMC Genomics. 2023 Apr 10;24(1):192. doi: 10.1186/s12864-023-09295-4.
9
Genome-wide association analysis of blood-pressure traits in African-ancestry individuals reveals common associated genes in African and non-African populations.全基因组关联分析揭示了非裔个体血压特征中的常见关联基因，这些基因在非洲和非非洲人群中都存在。
Am J Hum Genet. 2013 Sep 5;93(3):545-54. doi: 10.1016/j.ajhg.2013.07.010. Epub 2013 Aug 22.
10
Discovery and fine-mapping of kidney function loci in first genome-wide association study in Africans.首个在非裔人群中进行的全基因组关联研究发现并精细定位了肾功能相关位点。
Hum Mol Genet. 2021 Jul 28;30(16):1559-1568. doi: 10.1093/hmg/ddab088.

引用本文的文献

1
Genomic and Precision Medicine Approaches in Atherosclerotic Cardiovascular Disease: From Risk Prediction to Therapy-A Review.动脉粥样硬化性心血管疾病的基因组学和精准医学方法：从风险预测到治疗——综述
Biomedicines. 2025 Jul 14;13(7):1723. doi: 10.3390/biomedicines13071723.
2
The distribution of highly deleterious variants across human ancestry groups.高有害变异在人类祖先群体中的分布。
Proc Natl Acad Sci U S A. 2025 May 27;122(21):e2503857122. doi: 10.1073/pnas.2503857122. Epub 2025 May 23.
3
Improved genetic discovery and fine-mapping resolution through multivariate latent factor analysis of high-dimensional traits.

本文引用的文献

1
Molecular insights into the gating mechanisms of voltage-gated calcium channel Ca2.3.电压门控钙通道 Ca2.3 门控机制的分子见解。
Nat Commun. 2023 Jan 31;14(1):516. doi: 10.1038/s41467-023-36260-2.
2
Bayesian Genetic Colocalization Test of Two Traits Using coloc.使用coloc对两种性状进行贝叶斯遗传共定位测试
Curr Protoc. 2022 Dec;2(12):e627. doi: 10.1002/cpz1.627.
3
Flashfm-ivis: interactive visualization for fine-mapping of multiple quantitative traits.Flashfm-ivis：用于多个数量性状精细定位的交互式可视化工具。
通过对高维性状进行多变量潜在因子分析提高基因发现和精细定位分辨率。
Cell Genom. 2025 May 14;5(5):100847. doi: 10.1016/j.xgen.2025.100847. Epub 2025 Apr 11.
4
The breadth and impact of the Global Lipids Genetics Consortium.全球脂质遗传学联盟的广度和影响力。
Curr Opin Lipidol. 2025 Apr 1;36(2):61-70. doi: 10.1097/MOL.0000000000000966. Epub 2024 Dec 9.
5
Ancestrally diverse genome-wide association analysis highlights ancestry-specific differences in genetic regulation of plasma protein levels.祖先多样化的全基因组关联分析突出了血浆蛋白水平遗传调控中特定祖先的差异。
medRxiv. 2024 Sep 28:2024.09.27.24314500. doi: 10.1101/2024.09.27.24314500.
6
Genome-wide fine-mapping improves identification of causal variants.全基因组精细定位可提高因果变异的识别能力。
Res Sq. 2024 Aug 7:rs.3.rs-4759390. doi: 10.21203/rs.3.rs-4759390/v1.
7
Genome-wide fine-mapping improves identification of causal variants.全基因组精细定位可提高因果变异的识别率。
medRxiv. 2024 Aug 5:2024.07.18.24310667. doi: 10.1101/2024.07.18.24310667.
8
Genetic association and transferability for urinary albumin-creatinine ratio as a marker of kidney disease in four Sub-Saharan African populations and non-continental individuals of African ancestry.在四个撒哈拉以南非洲人群以及具有非洲血统的非非洲大陆个体中，尿白蛋白肌酐比值作为肾脏疾病标志物的遗传关联性及可转移性研究
Front Genet. 2024 May 15;15:1372042. doi: 10.3389/fgene.2024.1372042. eCollection 2024.
Bioinformatics. 2022 Sep 2;38(17):4238-4242. doi: 10.1093/bioinformatics/btac453.
4
Meta-analysis of sub-Saharan African studies provides insights into genetic architecture of lipid traits.对撒哈拉以南非洲研究的荟萃分析提供了对脂质特征遗传结构的深入了解。
Nat Commun. 2022 May 11;13(1):2578. doi: 10.1038/s41467-022-30098-w.
5
The power of genetic diversity in genome-wide association studies of lipids.遗传多样性在全基因组关联研究脂质中的作用。
Nature. 2021 Dec;600(7890):675-679. doi: 10.1038/s41586-021-04064-3. Epub 2021 Dec 9.
6
The flashfm approach for fine-mapping multiple quantitative traits.快速映射多点定量性状的 flashfm 方法。
Nat Commun. 2021 Oct 22;12(1):6147. doi: 10.1038/s41467-021-26364-y.
7
GWAS of allometric body-shape indices in UK Biobank identifies loci suggesting associations with morphogenesis, organogenesis, adrenal cell renewal and cancer.全基因组关联研究在英国生物库中的体型指数分析鉴定出与形态发生、器官发生、肾上腺细胞更新和癌症相关的位点。
Sci Rep. 2021 May 21;11(1):10688. doi: 10.1038/s41598-021-89176-6.
8
The GTEx Consortium atlas of genetic regulatory effects across human tissues.GTEx 联盟人类组织遗传调控效应图谱
Science. 2020 Sep 11;369(6509):1318-1330. doi: 10.1126/science.aaz1776.
9
Insights into malaria susceptibility using genome-wide data on 17,000 individuals from Africa, Asia and Oceania.利用来自非洲、亚洲和大洋洲的 17000 个人的全基因组数据洞察疟疾易感性。
Nat Commun. 2019 Dec 16;10(1):5732. doi: 10.1038/s41467-019-13480-z.
10
Uganda Genome Resource Enables Insights into Population History and Genomic Discovery in Africa.乌干达基因组资源促进了对非洲人口历史和基因组发现的深入了解。
Cell. 2019 Oct 31;179(4):984-1002.e36. doi: 10.1016/j.cell.2019.10.004.