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老年人使用多种药物时与奈玛特韦-利托那韦的药物相互作用。

Drug Interactions With Nirmatrelvir-Ritonavir in Older Adults Using Multiple Medications.

机构信息

Faculty of Medicine and Health Sciences, McGill University, Montreal, Quebec, Canada.

Centre for Outcomes Research and Evaluation, McGill University Health Centre, Montreal, Quebec, Canada.

出版信息

JAMA Netw Open. 2022 Jul 1;5(7):e2220184. doi: 10.1001/jamanetworkopen.2022.20184.

DOI:10.1001/jamanetworkopen.2022.20184
PMID:35793089
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9260479/
Abstract

This quality improvement study uses data from the MedSafer trial to evaluate drug-drug interactions between nirmatrelvir-ritonavir and maintenance medications to identify use of potentially inappropriate medications in older adults with polypharmacy.

摘要

本质量改进研究使用了 MedSafer 试验的数据，评估了奈玛特韦-利托那韦与维持性药物之间的药物相互作用，以确定在服用多种药物的老年患者中潜在不适当药物的使用情况。

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本文引用的文献

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Oral Nirmatrelvir for High-Risk, Nonhospitalized Adults with Covid-19.奈玛特韦片/利托那韦片组合包装口服药用于伴有进展为重症高风险因素的 COVID-19 门诊患者。
N Engl J Med. 2022 Apr 14;386(15):1397-1408. doi: 10.1056/NEJMoa2118542. Epub 2022 Feb 16.
2
Nirmatrelvir-ritonavir for COVID-19.用于治疗新冠肺炎的奈玛特韦片/利托那韦片组合包装
CMAJ. 2022 Feb 14;194(6):E218. doi: 10.1503/cmaj.220081. Epub 2022 Feb 3.
3
The MedSafer Study-Electronic Decision Support for Deprescribing in Hospitalized Older Adults: A Cluster Randomized Clinical Trial.《MedSafer 研究-电子决策支持在老年住院患者中减药的应用：一项集群随机临床试验》。
JAMA Intern Med. 2022 Mar 1;182(3):265-273. doi: 10.1001/jamainternmed.2021.7429.
4
SQUIRE 2.0 (Standards for QUality Improvement Reporting Excellence): revised publication guidelines from a detailed consensus process.SQUIRE 2.0（卓越质量改进报告标准）：通过详细的共识过程制定的修订版出版指南。
BMJ Qual Saf. 2016 Dec;25(12):986-992. doi: 10.1136/bmjqs-2015-004411. Epub 2015 Sep 14.