Global Burden of Animal Diseases Programme https://animalhealthmetrics.org.
Centre for Biosecurity and One Health, Harry Butler Institute, Murdoch University, Perth, Australia.
PLoS Negl Trop Dis. 2022 Jul 6;16(7):e0010567. doi: 10.1371/journal.pntd.0010567. eCollection 2022 Jul.
Taenia solium is the most significant global foodborne parasite and the leading cause of preventable human epilepsy in low and middle-income countries in the form of neurocysticercosis.
This scoping review aimed to examine the methodology of peer-reviewed studies that estimate the burden of T. solium using disability-adjusted life years.
Studies must have calculated disability-adjusted life years relating to T. solium.
The review process was managed by a single reviewer using Rayyan. Published data relating to disease models, data sources, disability-adjusted life years, sensitivity, uncertainty, missing data, and key limitations were collected.
15 studies were included for review, with seven global and eight national or sub-national estimates. Studies primarily employed attributional disease models that relied on measuring the occurrence of epilepsy before applying an attributable fraction to estimate the occurrence of neurocysticercosis-associated epilepsy. This method relies heavily on the extrapolation of observational studies across populations and time periods; however, it is currently required due to the difficulties in diagnosing neurocysticercosis. Studies discussed that a lack of data was a key limitation and their results likely underestimate the true burden of T. solium. Methods to calculate disability-adjusted life years varied across studies with differences in approaches to time discounting, age weighting, years of life lost, and years of life lived with disability. Such differences limit the ability to compare estimates between studies.
This review illustrates the complexities associated with T. solium burden of disease studies and highlights the potential need for a burden of disease reporting framework. The burden of T. solium is likely underestimated due to the challenges in diagnosing neurocysticercosis and a lack of available data. Advancement in diagnostics, further observational studies, and new approaches to parameterising disease models are required if estimates are to improve.
猪带绦虫是最重要的食源性全球寄生虫，也是中低收入国家以神经囊虫病形式导致可预防人类癫痫的主要原因。
本范围综述旨在检查使用残疾调整生命年来估计猪带绦虫负担的同行评审研究的方法学。
必须计算与猪带绦虫相关的残疾调整生命年的研究。
审查过程由一名审阅者使用 Rayyan 进行管理。收集了与疾病模型、数据源、残疾调整生命年、敏感性、不确定性、缺失数据和关键限制相关的已发表数据。
纳入了 15 项研究进行综述，其中包括 7 项全球研究和 8 项国家或次国家估计。研究主要采用归因疾病模型，该模型依赖于测量癫痫的发生，然后应用归因分数来估计神经囊虫病相关癫痫的发生。这种方法严重依赖于将观察性研究外推到不同人群和时间段；然而，由于诊断神经囊虫病的困难，目前需要这种方法。研究讨论了数据缺乏是一个关键限制，他们的结果可能低估了猪带绦虫的真实负担。残疾调整生命年的计算方法在研究之间存在差异，表现在时间贴现、年龄加权、生命损失年和生命残疾年的方法上存在差异。这些差异限制了在研究之间比较估计的能力。
本综述说明了与猪带绦虫疾病负担研究相关的复杂性，并强调了可能需要一个疾病负担报告框架。由于诊断神经囊虫病的挑战和缺乏可用数据，猪带绦虫的负担可能被低估。如果要改善估计，就需要在诊断方面取得进展、进行更多的观察性研究以及采用新的疾病模型参数化方法。
