College of Food Science, South China Agricultural University, Guangdong Provincial Key Laboratory of Food Quality and Safety, Guangzhou, PR China.
Guangdong Testing Institute of Product Quality Supervision, Guangzhou, PR China.
Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2022 Sep;39(9):1591-1603. doi: 10.1080/19440049.2022.2094474. Epub 2022 Jul 6.
Phthalic acid esters (PAEs) are typical endocrine disruptors which are ubiquitous contaminants. Human exposure to PAEs is through multiple routes of which the diet is recognised as the main source of daily intake. The aim of this study was to evaluate the dietary exposure to PAEs of residents in Shenzhen (China) through a total diet study and assess the potential health risk. A total of 16 different phthalate esters in samples of 12 composite food groups were determined by GC-MS. The main dietary sources of PAE exposure among adult residents in Shenzhen were potatoes (21%), eggs (21%), meat (15%) and aquatic products (14%). The median total dietary exposure to PAEs in Shenzhen residents was 7780 ng kg bw d, and the hazard quotients (HQ) of dimethyl phthalate (DMP), diethyl phthalate (DEP), di-isobutyl phthalate (DIBP), dibutyl phthalate (DBP) and di-2-ethylhexyl phthalate (DEHP) were 0.09, 0.06, 0.07, 0.10 and 0.03, respectively. Therefore, the risks from dietary PAE exposure were low. However, with the increasing use of PAEs and their accumulation in the environment, the probability of PAEs entering the food chain is gradually increasing and, therefore, PAEs should be strictly controlled and regularly monitored.
邻苯二甲酸酯（PAEs）是一种普遍存在的环境污染物，属于典型的内分泌干扰物。人类主要通过饮食途径接触 PAEs，饮食已被公认为是人类日常摄入 PAEs 的主要来源。本研究通过总膳食研究评估了深圳居民的 PAE 膳食暴露水平，并评估了其潜在健康风险。采用 GC-MS 法测定了 12 种混合食品中 16 种不同的邻苯二甲酸酯。深圳成年居民的主要 PAE 膳食来源为土豆（21%）、鸡蛋（21%）、肉类（15%）和水产品（14%）。深圳居民的总膳食 PAE 暴露中位数为 7780ngkgbw d，其中 DMP、DEP、DIBP、DBP 和 DEHP 的危害系数（HQ）分别为 0.09、0.06、0.07、0.10 和 0.03。因此，来自膳食 PAE 暴露的风险较低。然而，随着 PAEs 的使用增加及其在环境中的积累，PAEs 进入食物链的概率逐渐增加，因此应严格控制和定期监测 PAEs。
