从神经免疫代谢角度看胰岛素分泌的头期。

A neuroimmunometabolic view on the cephalic phase of insulin release.

机构信息

Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.

出版信息

Cell Metab. 2022 Jul 5;34(7):940-942. doi: 10.1016/j.cmet.2022.06.005.

DOI:10.1016/j.cmet.2022.06.005

Abstract

The cephalic phase of insulin secretion (CPIS) plays a crucial role in glucose homeostasis. However, the neural basis of CPIS and its overall relevance to metabolic health are poorly understood. Here, we preview the findings of Wiedemann et al. (2022) that address the role of IL-1β in the integration of neuro-mediated insulin release following cephalic stimulation and CPIS dysregulation in obesity.

摘要

胰岛素分泌的头相（CPIS）在血糖稳态中起着至关重要的作用。然而，CPIS 的神经基础及其对代谢健康的整体相关性仍知之甚少。在这里，我们先睹为快 Wiedemann 等人（2022 年）的研究结果，该研究探讨了白细胞介素-1β（IL-1β）在头相刺激后神经介导的胰岛素释放整合以及肥胖时 CPIS 失调中的作用。