Farkas W R, Fischbein A, Solomon S, Buschman F, Borek E, Sharma O K
Arch Environ Health. 1987 Mar-Apr;42(2):96-9. doi: 10.1080/00039896.1987.9935803.
beta-Aminoisobutyric acid (beta-AIB), a normal degradation product of thymine, a constituent of DNA and, to a lesser extent, of transfer RNA, is excreted in low levels in human urine. We found that a group of iron workers occupationally exposed to inorganic lead excreted high levels of urinary beta-AIB. Elevated urinary excretion of beta-AIB was also observed in marmosets, Callithrix jacchus, that received lead acetate in drinking water. Our results suggest that increased urinary excretion of beta-AIB could stem from damage to DNA on exposure to lead.
β-氨基异丁酸（β-AIB）是胸腺嘧啶的正常降解产物，胸腺嘧啶是DNA的组成成分，在较小程度上也是转运RNA的组成成分，它在人类尿液中的排泄量较低。我们发现，一组职业性接触无机铅的钢铁工人尿中β-AIB排泄量很高。在饮用含醋酸铅的水的狨猴（Callithrix jacchus）中也观察到β-AIB尿排泄量升高。我们的结果表明，β-AIB尿排泄量增加可能源于接触铅导致的DNA损伤。
