Universidade Federal de Goias, Instituto de Patologia Tropical e Saude Publica, Goiania, Brazil.
School of Applied Mathematics, Fundacao Getulio Vargas, Rio de Janeiro, Brazil.
Int J Infect Dis. 2022 Sep;122:521-528. doi: 10.1016/j.ijid.2022.06.050. Epub 2022 Jul 3.
Dengue infection is a growing public health problem, with the number of reported cases increasing in the Americas and worldwide. This review characterized the epidemiological and economic burden of dengue in Brazil.
Embase, MEDLINE, evidence-based review databases, and gray literature sources were searched for published literature and surveillance reports on epidemiology (between 2000 and 2019) and costs (between 2009 and 2019) of dengue in Brazil. Studies were included if they reported data on incidence, seroprevalence, serotype distribution, expansion factors, hospitalization, mortality, or costs. Data were summarized descriptively and reported following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.
A total of 344 publications were included (167 peer-reviewed and 177 gray literature). Dengue outbreaks increased in incidence and frequency, with the highest incidence observed in 2015 at 807 cases per 100,000 population. Outbreaks were related to alternating predominant serotypes. Dengue was more frequent in young adults (aged 20-39 years) and in the Midwest. Cost and societal impacts are substantial and varied across regions, age, and public/private delivery of healthcare services.
The burden of dengue in Brazil is increasing and likely underestimated. Therefore, developing and implementing new strategies, including vaccination, is essential to reduce the disease burden.
登革热感染是一个日益严重的公共卫生问题，美洲和全球报告的病例数量都在增加。本研究旨在描述巴西登革热的流行病学和经济负担。
检索 Embase、MEDLINE、循证医学数据库和灰色文献资源，以获取 2000 年至 2019 年间巴西登革热流行病学（发病率、血清流行率、血清型分布、扩大因素、住院、死亡率）和成本（2009 年至 2019 年）的发表文献和监测报告。如果研究报告了发病率、血清流行率、血清型分布、扩大因素、住院、死亡率或成本的数据，则纳入研究。数据以描述性方式进行总结，并按照系统评价和荟萃分析的首选报告项目进行报告。
共纳入 344 篇文献（167 篇同行评议文献和 177 篇灰色文献）。登革热的发病率和频率不断增加，2015 年发病率最高，达到每 10 万人 807 例。疫情与交替流行的主要血清型有关。登革热在年轻人（20-39 岁）和中西部更为常见。成本和社会影响是巨大的，因地区、年龄和公共/私人医疗服务的提供而有所不同。
巴西登革热的负担正在增加，而且可能被低估了。因此，制定和实施新的策略，包括疫苗接种，对于减轻疾病负担至关重要。
