Tropical Infectious Disease Research and Education Centre (TIDREC); World Health Organization Collaborating Centre for Arbovirus Reference and Research (Dengue and Severe Dengue), Universiti Malaya, Kuala Lumpur, Malaysia.
Faculty of Medicine, National University of Malaysia, Selangor, Malaysia.
Int J Infect Dis. 2022 Nov;124:240-247. doi: 10.1016/j.ijid.2022.09.006. Epub 2022 Sep 9.
A systematic literature review was conducted to assess the epidemiology and economic burden of dengue in Malaysia.
Embase, MEDLINE, Evidence-Based Reviews databases, and gray literature sources were searched for English and Malay studies and surveillance reports on the epidemiology (between 2012 and 2019) and costs (between 2009 and 2019) of dengue in Malaysia. Independent screening of titles/abstracts, followed by full texts was performed using prespecified criteria.
A total of 198 publications were included (55 peer-reviewed and 143 gray literature). Dengue incidence has been increasing in recent years, with 130,101 cases (dengue fever 129,578 cases; dengue hemorrhagic fever 523 cases) reported in 2019, which is the highest since 2012. All dengue virus serotypes co-circulated between 2004 and 2017, and major outbreaks occurred in a cyclical pattern, often associated with a change in the predominant circulating serotype. Economic impacts are substantial, including the societal impact of lost work (7.2-8.8 days) and school days (3.2-4.1 days) due to dengue.
The rising incidence and high cost of dengue, coupled with overlapping diseases, will likely result in further pressures on the healthcare system. To appropriately mitigate and control dengue, it is critical to implement integrated strategies, including vaccination, to reduce the burden of dengue.
系统文献回顾旨在评估马来西亚登革热的流行病学和经济负担。
检索了 Embase、MEDLINE、循证评论数据库和灰色文献来源，以获取关于马来西亚登革热的流行病学（2012 年至 2019 年）和成本（2009 年至 2019 年）的英文和马来文研究和监测报告。使用预设标准对标题/摘要进行独立筛选，然后进行全文筛选。
共纳入 198 篇文献（55 篇同行评议文献和 143 篇灰色文献）。近年来，登革热发病率呈上升趋势，2019 年报告了 130101 例病例（登革热 129578 例；登革出血热 523 例），这是自 2012 年以来的最高水平。2004 年至 2017 年间，所有登革热病毒血清型均同时流行，主要疫情呈周期性发生，通常与主要流行血清型的变化有关。经济影响巨大，包括因登革热导致的劳动力（7.2-8.8 天）和学校日（3.2-4.1 天）损失的社会影响。
登革热发病率上升和成本高昂，加上重叠疾病，可能会对医疗保健系统造成进一步压力。为了适当减轻和控制登革热，必须实施综合战略，包括接种疫苗，以减轻登革热的负担。
