Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine.
Department of Public Health, Division of Preventive Medicine, Hokkaido University, Graduate School of Medicine.
J Atheroscler Thromb. 2023 Apr 1;30(4):408-414. doi: 10.5551/jat.63416. Epub 2022 Jul 6.
Evidence of the effects of physical activity on mortality from aortic diseases, especially in Asian populations, remains limited. This study aimed to examine these effects using data from a large long-term cohort study of Japanese men and women.
Between 1988 and 1990, 32,083 men and 43,454 women in Japan, aged 40-79 years with no history of coronary heart disease, stroke, aortic diseases, or cancer, filled in questionnaires on time spent walking and participating in sports and were followed up until 2009. Multivariable hazard ratios (HRs) with 95% confidence intervals (CIs) of aortic disease mortality and its types (aortic aneurysm and dissection) according to the time spent walking and participating in sports were calculated after adjusting for potential confounding factors using the Cox proportional hazards model.
During a median follow-up of 19.1 years, a total of 173 deaths from aortic disease (91 cases of aortic dissection and 82 of aortic aneurysm) were documented. Sports participation time was inversely associated with the risk of death from aortic aneurysm: the multivariable HRs (95% CIs) were 0.68 (0.40-1.16) for ＜1 h/week, 0.50 (0.19-1.35) for 3-4 h/week, and 0.31 (0.10-0.93) for ≥ 5 h/week (p for trend=0.23) compared with 1-2 h/week. The time spent walking was not associated with death from aortic aneurysm, dissection, and total aortic diseases.
Greater time spent in sports participation was associated with a reduced risk of mortality from aortic aneurism in the Japanese population. Further studies are needed to investigate the relationship between physical activity and aortic dissection.
关于体力活动对主动脉疾病死亡率的影响，尤其是在亚洲人群中的影响，证据仍然有限。本研究旨在利用日本男性和女性大型长期队列研究的数据来检验这些影响。
1988 年至 1990 年，日本年龄在 40-79 岁、无冠心病、中风、主动脉疾病或癌症病史的 32083 名男性和 43454 名女性填写了关于步行和运动时间的问卷，并随访至 2009 年。使用 Cox 比例风险模型，在调整潜在混杂因素后，计算根据步行和运动时间的主动脉疾病死亡率及其类型（主动脉瘤和夹层）的多变量风险比（HR）和 95%置信区间（CI）。
在中位数为 19.1 年的随访期间，共记录了 173 例主动脉疾病死亡（91 例主动脉夹层和 82 例主动脉瘤）。运动参与时间与主动脉瘤死亡风险呈负相关：多变量 HR（95%CI）分别为每周<1 小时为 0.68（0.40-1.16），每周 3-4 小时为 0.50（0.19-1.35），每周≥5 小时为 0.31（0.10-0.93）（趋势检验 p=0.23），与每周 1-2 小时相比。步行时间与主动脉瘤、夹层和总主动脉疾病的死亡率无关。
更多的运动时间与日本人群中主动脉瘤死亡率降低相关。需要进一步的研究来调查体力活动与主动脉夹层之间的关系。
