Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan; Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Atherosclerosis. 2017 Aug;263:145-150. doi: 10.1016/j.atherosclerosis.2017.06.022. Epub 2017 Jun 9.
Evidence on the association between passive smoking and risk of aortic dissection or aneurysm is limited. This study aimed to investigate whether passive smoking increases risk of mortality from aortic dissection or aneurysm.
The Japan Collaborative Cohort (JACC) Study is a prospective community-based cohort study begun in 1988-90 and followed up to the end of 2009. We examined 48,677 individuals (mean age, 56 years; women, 46%) without history of stroke, coronary heart disease, or cancer, who provided valid responses to a lifestyle questionnaire including questions on active and passive smoking. We used 3 categories (passive smoking out of home, passive smoking at home, and passive smoking out of or at home combined) to divide never-smokers into 3 exposure groups: low, intermediate, and high exposures, respectively. The endpoint was underlying cause of death from aortic dissection or aneurysm.
During the median 19-year follow-up of 48,677 study participants, 66 died of aortic dissection, and 75 of aortic aneurysm. Multivariable hazard ratios (95% confidence intervals) for the high passive-smoking group as compared with the low passive-smoking group were 2.45 (1.02-5.88) out of home, 1.82 (0.84-3.96) at home, and 2.35 (1.09-5.09) out of or at home combined. The corresponding hazard ratios for current smokers as compared with the low passive-smoking group were 3.97 (2.14-7.39), 3.41 (1.84-6.32) and 4.09 (1.99-8.39), respectively.
Out-of-home passive smoking and out-of- or at-home combined passive smoking were associated with increased mortality from aortic dissection or aneurysm.
有关被动吸烟与主动脉夹层或动脉瘤风险之间关联的证据有限。本研究旨在探讨被动吸烟是否会增加主动脉夹层或动脉瘤导致的死亡率。
日本合作队列研究（JACC）是一项始于 1988-90 年并随访至 2009 年底的前瞻性社区为基础的队列研究。我们共检查了 48677 名无中风、冠心病或癌症病史且对包括主动和被动吸烟问题的生活方式问卷做出有效应答的个体（平均年龄 56 岁，女性占 46%）。我们使用 3 个类别（家庭外被动吸烟、家庭内被动吸烟和家庭内外联合被动吸烟）将从不吸烟者分为 3 个暴露组：低、中、高暴露组。研究终点为主动脉夹层或动脉瘤的根本死因。
在 48677 名研究参与者中位 19 年的随访期间，共有 66 人死于主动脉夹层，75 人死于主动脉瘤。与低暴露组相比，高家庭外被动吸烟组、家庭内被动吸烟组和家庭内外联合被动吸烟组的多变量危险比（95%置信区间）分别为 2.45（1.02-5.88）、1.82（0.84-3.96）和 2.35（1.09-5.09）。与低暴露组相比，当前吸烟者的相应危险比分别为 3.97（2.14-7.39）、3.41（1.84-6.32）和 4.09（1.99-8.39）。
家庭外被动吸烟和家庭内外联合被动吸烟与主动脉夹层或动脉瘤所致死亡率升高相关。
