环状RNA hsa_circ_0012673通过miR-576-3p/SOX4轴促进乳腺癌进展。

Circular RNA hsa_circ_0012673 Promotes Breast Cancer Progression via miR-576-3p/SOX4 Axis.

作者信息

Qiu Xiangmei, Zhang Qiang, Deng Qingfang, Li Quan

机构信息

Department of Obstetrics and Gynecology, Affiliated Hospital of Zunyi Medical University, 149 Dalian Road, Huichuan District, Zunyi, 563000, Guizhou, China.

出版信息

Mol Biotechnol. 2023 Jan;65(1):61-71. doi: 10.1007/s12033-022-00524-x. Epub 2022 Jul 6.

DOI:10.1007/s12033-022-00524-x

PMID:35794450

Abstract

Circular RNAs (circRNAs) have been reported to exert critical roles in human cancers. In this study, we investigated the role and molecular mechanism of hsa_circ_0012673 in breast cancer. Herein, we found that the expression of hsa_circ_0012673 was upregulated in breast cancer tissues and cell lines. Knockdown of hsa_circ_0012673 using RNA interference technique suppressed the proliferation, migration, and invasion of breast cancer cells. Mechanistically, hsa_circ_0012673 sponged miR-576-3p to stabilize SRY-box transcription factor 4 (SOX4), and thereby facilitating breast cancer cell proliferation, migration and invasion. Collectively, our study identified the oncogenic properties of hsa_circ_0012673/miR-576-3p/SOX4 axis in breast cancer, providing potential and exploitable diagnostic and therapeutic molecules for breast cancer.

摘要

据报道，环状RNA（circRNAs）在人类癌症中发挥着关键作用。在本研究中，我们调查了hsa_circ_0012673在乳腺癌中的作用及其分子机制。在此，我们发现hsa_circ_0012673在乳腺癌组织和细胞系中表达上调。使用RNA干扰技术敲低hsa_circ_0012673可抑制乳腺癌细胞的增殖、迁移和侵袭。机制上，hsa_circ_0012673作为miR-576-3p的海绵，稳定了SRY盒转录因子4（SOX4），从而促进乳腺癌细胞的增殖、迁移和侵袭。总的来说，我们的研究确定了hsa_circ_0012673/miR-576-3p/SOX4轴在乳腺癌中的致癌特性，为乳腺癌提供了潜在的、可利用的诊断和治疗分子。