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人源环状RNA hsa_circ_0053063通过hsa_circ_0053063/hsa-miR-330-3p/程序性细胞死亡蛋白4轴抑制乳腺癌细胞增殖。

Hsa_circ_0053063 inhibits breast cancer cell proliferation via hsa_circ_0053063/hsa-miR-330-3p/PDCD4 axis.

作者信息

Ji Changle, Hu Jiashu, Wang Xuehui, Zheng Wenfang, Deng Xiaochong, Song Hongming, Yu Yunhe, Luo Qifeng, Hua Kaiyao, Zhou Xiqian, Fang Lin

机构信息

Department of Breast and Thyroid Surgery, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China.

Tongji University School of Medicine, Shanghai 200092, China.

出版信息

Aging (Albany NY). 2021 Mar 19;13(7):9627-9645. doi: 10.18632/aging.202707.

DOI:10.18632/aging.202707
PMID:33744861
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8064214/
Abstract

Breast cancer (BC) is one of the most common malignancies and its mortality is the highest among females. Circular RNAs (circRNAs), a novel group of non-coding RNAs, play an important regulatory role in angiogenesis and cancer progression. Hsa_circ_0053063 is a circRNA generated from several exons of HADHA. The potential role of hsa_circ_0053063 in BC remains unknown and needs to be explored. Hsa_circ_0053063 was mainly located in the cytoplasm and activated in BC tissues and cell lines. The binding position between hsa_circ_0053063 and miR-330-3p was confirmed by luciferase reporter assay. Moreover, hsa_circ_0053063 inhibited cell viability, proliferation, and progression of BC through the negative regulation of miR-330-3p. Programmed cell death 4 (PDCD4) is a direct target of miR-330-3p. Besides, the over-expression of miR-330-3p promoted cell progression by directly targeting and regulating PDCD4. Mechanistically, hsa_circ_0053063 activated PDCD4 by targeting miR-330-3p to inhibit BC progression. In conclusion, hsa_circ_0053063 inhibits breast cancer cell proliferation via hsa_circ_0053063/hsa-miR-330-3p/PDCD4 axis, which may provide a new therapeutic target for BC patients.

摘要

乳腺癌（BC）是最常见的恶性肿瘤之一，其死亡率在女性中最高。环状RNA（circRNAs）是一类新型非编码RNA，在血管生成和癌症进展中发挥重要调控作用。hsa_circ_0053063是一种由HADHA的几个外显子产生的环状RNA。hsa_circ_0053063在乳腺癌中的潜在作用尚不清楚，有待探索。hsa_circ_0053063主要位于细胞质中，在乳腺癌组织和细胞系中被激活。荧光素酶报告基因检测证实了hsa_circ_0053063与miR-330-3p之间的结合位点。此外，hsa_circ_0053063通过对miR-330-3p的负调控抑制乳腺癌细胞的活力、增殖和进展。程序性细胞死亡4（PDCD4）是miR-330-3p的直接靶标。此外，miR-330-3p的过表达通过直接靶向和调控PDCD4促进细胞进展。机制上，hsa_circ_0053063通过靶向miR-330-3p激活PDCD4以抑制乳腺癌进展。总之，hsa_circ_0053063通过hsa_circ_0053063/hsa-miR-330-3p/PDCD4轴抑制乳腺癌细胞增殖，这可能为乳腺癌患者提供新的治疗靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b17c/8064214/fccffb0a4c1c/aging-13-202707-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b17c/8064214/336fc07fd257/aging-13-202707-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b17c/8064214/a9cd483d54c0/aging-13-202707-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b17c/8064214/61fc498d30ed/aging-13-202707-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b17c/8064214/75d5ba0fdca3/aging-13-202707-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b17c/8064214/fccffb0a4c1c/aging-13-202707-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b17c/8064214/336fc07fd257/aging-13-202707-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b17c/8064214/36c5a42dcc7e/aging-13-202707-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b17c/8064214/e514d9c3eb17/aging-13-202707-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b17c/8064214/a9cd483d54c0/aging-13-202707-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b17c/8064214/61fc498d30ed/aging-13-202707-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b17c/8064214/75d5ba0fdca3/aging-13-202707-g009.jpg
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