Department of Biochemistry, Faculty of Veterinary Medicine, Damanhour University, Damanhour, Egypt.
Department of Hematology/Pediatric Oncology, Yousef Abdulatif Jameel Scientific Chair of Prophetic Medicine Application, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Phytother Res. 2022 Aug;36(8):3181-3201. doi: 10.1002/ptr.7534. Epub 2022 Jul 6.
Glycolysis is the primary source of energy for cancer growth and metastasis. The shift in metabolism from mitochondrial oxidative phosphorylation to aerobic glycolysis is called the Warburg effect. Cancer progression due to aerobic glycolysis is often associated with the activation of oncogenes or the loss of tumor suppressors. Therefore, inhibition of glycolysis is one of the effective strategies in cancer control. Pyruvate kinase M2 (PKM2) is a key glycolytic enzyme overexpressed in breast, prostate, lung, colorectal, and liver cancers. Here, we discuss published studies regarding PKM2 inhibitors from natural products that are promising drug candidates for cancer therapy. We have highlighted the potential of natural PKM2 inhibitors for various cancer types. Moreover, we encourage researchers to evaluate the combinational effects between natural and synthetic PKM2 inhibitors. Also, further high-quality studies are needed to firmly establish the clinical efficacy of natural products.
糖酵解是癌症生长和转移的主要能量来源。代谢从线粒体氧化磷酸化向有氧糖酵解的转变称为瓦博格效应。有氧糖酵解导致的癌症进展通常与癌基因的激活或肿瘤抑制因子的丢失有关。因此，抑制糖酵解是癌症控制的有效策略之一。丙酮酸激酶 M2（PKM2）是一种在乳腺癌、前列腺癌、肺癌、结直肠癌和肝癌中过度表达的关键糖酵解酶。在这里，我们讨论了关于天然产物中 PKM2 抑制剂的已发表研究，这些抑制剂是癌症治疗有前景的候选药物。我们强调了天然 PKM2 抑制剂对各种癌症类型的潜力。此外，我们鼓励研究人员评估天然和合成 PKM2 抑制剂之间的组合效应。还需要进一步的高质量研究来确定天然产物的临床疗效。
