Hu Mengjie, Zheng Kaijie, Zhang Lijiao, Kan Yue, Zhao Jiaqian, Chen Dajing
School of Pharmacy, Hangzhou Normal University, Hangzhou 311121, China.
Cells. 2025 Aug 19;14(16):1288. doi: 10.3390/cells14161288.
Cancer cells predominantly utilize aerobic glycolysis for energy production, preferentially converting glucose (Glu) to pyruvate (PA) and subsequently to lactate (LA). This metabolic reprogramming results in extracellular LA accumulation, acidifying the tumor microenvironment (TME) and facilitating tumor invasion and metastasis. The dynamics of Glu, PA, and LA are pivotal to tumor initiation and progression. This review comprehensively discussed therapeutic strategies targeting these key metabolites and systematically evaluates electrochemical and fluorescence-based techniques for their dynamic monitoring. We highlight the critical role of these monitoring approaches in advancing early cancer diagnosis, enabling personalized treatment, and accelerating anticancer drug development.
癌细胞主要利用有氧糖酵解来产生能量，优先将葡萄糖（Glu）转化为丙酮酸（PA），随后再转化为乳酸（LA）。这种代谢重编程导致细胞外乳酸积累，使肿瘤微环境（TME）酸化，并促进肿瘤侵袭和转移。葡萄糖、丙酮酸和乳酸的动态变化对于肿瘤的发生和发展至关重要。本文综述全面讨论了针对这些关键代谢物的治疗策略，并系统评估了基于电化学和荧光的动态监测技术。我们强调了这些监测方法在推进早期癌症诊断、实现个性化治疗以及加速抗癌药物开发方面的关键作用。
