Predictors of Occurrence and 30-Day Mortality for Co-Infection of Carbapenem-Resistant and Carbapenem-Resistant .

BACKGROUND

The phenomenon of co-infection with multiple carbapenem-resistant bacteria is growing, which pose a great challenge for infection control and treatment. This study aimed to analyze predictors of occurrence and 30-day mortality for carbapenem-resistant and carbapenem-resistant co-infection.

METHODS

From June 2018 to June 2021, clinical data of 103 patients co-infected with carbapenem-resistant (CRAB) and carbapenem-resistant (CRKP) were collected from a tertiary teaching hospital in Anhui Province, China. The clinical characteristics and predictors of mortality were analyzed. Meanwhile, the bacterial isolates were characterized for drug susceptibility, multi-locus sequence typing, and drug resistance genes.

RESULTS

The multivariate analysis revealed that fiberoptic bronchoscopy ( = 0.005, OR=2.72), repeat transfusions ( = 0.008, OR= 2.23) and exposure to tigecycline ( = 0.002, OR = 6.58) were independent risk factors for CRKP and CRAB co-infection. Neutrophil ≥11.9*10 ( = 0.035, adjusted HR = 3.12) and C-reactive protein ≥ 149 mg/L ( = 0.009, adjusted HR = 4.41) were found associated with 30-day mortality. Combined neutrophil with C-reactive protein could predict 30-day mortality, of which AUC value was 0.791 (95%CI: 0.661-0.921). KPC (46/51, 90.2%) was the most common carbapenemase in CRKP. 33 isolates of CRKP belong to (33/51, 64.7%), and three new ST types were detected.

CONCLUSIONS

Invasive operations and antibiotics exposure can lead to CRKP and CRAB co-infection. Combined neutrophil with C-reactive protein could predict 30-day mortality.