Cardio-Thoracic Surgery, Affiliated Hospital of Nanjing University of Chinese Medicine, 210029 Nanjing, Jiangsu Province, China.
Contrast Media Mol Imaging. 2022 May 24;2022:8330111. doi: 10.1155/2022/8330111. eCollection 2022.
To analyze multiple factors developing lung adenocarcinoma lesion from solitary pulmonary nodule (SPN).
A total of 70 patients diagnosed with lung adenocarcinoma after finding SPN by chest CT and treated in our hospital (01, 2018-01, 2021) were selected as the malignant lesion group, and another 70 patients diagnosed with benign lesion after finding SPN by CT in the same period were included in the benign lesion group. All patients had complete medical records. With univariate analysis and multivariate logistic regression, the independent risk factors for developing lung adenocarcinoma lesions from SPN were analyzed.
By conducting univariate analysis of patients' general information (age, course of disease, BMI, nodule diameter, and gender), smoking status (smoking history and number of cigarettes smoked per year), medical history (family history of lung cancer, history of extrapulmonary malignant tumor, and history of autoimmune diseases), basic complications (hypertension and diabetes), and laboratory examinations (CEA, NSE, CYFRA21-1, SCC-Ag, and CA125), it was concluded that age, course of disease, nodule diameter, CEA positive, CYFRA21-1 positive, and CA125 positive were significantly different between the two groups ( < 0.05); the logistic regression results showed that high age, increased nodule diameter, and CYFRA21-1 positive were the independent risk factors developing lung adenocarcinoma from SPN ( < 0.05).
In patients with SPN, higher age, longer course of disease, greater nodule diameter, and CYFRA21-1 positive imply increased risk for triggering lung adenocarcinoma lesion. Therefore, high attention should be paid in the clinic to such SPN patients for early diagnosis and treatment.
分析从肺部孤立性结节（SPN）发展为肺腺癌的多种因素。
选取我院经胸部 CT 发现 SPN 后确诊为肺腺癌的 70 例患者（2018 年 1 月 1 日至 2021 年 1 月 1 日）为恶性病变组，同期经 CT 发现 SPN 后确诊为良性病变的 70 例患者纳入良性病变组。所有患者均有完整的病历资料。采用单因素分析和多因素 logistic 回归分析，分析 SPN 发展为肺腺癌的独立危险因素。
对患者的一般资料（年龄、病程、BMI、结节直径、性别）、吸烟状况（吸烟史和每年吸烟支数）、既往病史（肺癌家族史、肺外恶性肿瘤史、自身免疫性疾病史）、基础并发症（高血压、糖尿病）、实验室检查（CEA、NSE、CYFRA21-1、SCC-Ag、CA125）进行单因素分析，发现两组患者在年龄、病程、结节直径、CEA 阳性、CYFRA21-1 阳性、CA125 阳性方面差异有统计学意义（ < 0.05）；logistic 回归结果显示，高龄、结节直径增大、CYFRA21-1 阳性是 SPN 发展为肺腺癌的独立危险因素（ < 0.05）。
在 SPN 患者中，高龄、病程长、结节直径大、CYFRA21-1 阳性提示发生肺腺癌病变的风险增加。因此，临床应高度重视此类 SPN 患者，以便早期诊断和治疗。
