ENT and Cervicofacial Surgery Department, Fundación Jiménez Díaz University Hospital, Madrid, Spain.
ENT and Cervicofacial Surgery Department, Villalba General University Hospital, Collado Villalba, Spain.
Emerg Microbes Infect. 2022 Dec;11(1):1833-1842. doi: 10.1080/22221751.2022.2098059.
Background: studies have shown that several oral antiseptics have virucidal activity against SARS-CoV-2. Thus, mouthwashes have been proposed as an easy to implement strategy to reduce viral transmission. However, there are no data measuring SARS-CoV-2 viability after mouthwashes .
In this randomized double-blind, five-parallel-group, placebo-controlled clinical trial, SARS-CoV-2 salivary viral load (by quantitative PCR) and its infectious capacity (incubating saliva in cell cultures) have been evaluated before and after four different antiseptic mouthwashes and placebo in 54 COVID-19 patients.
Contrary to evidence, salivary viral load was not affected by any of the four tested mouthwashes. Viral culture indicated that cetylpyridinium chloride (CPC) significantly reduced viral infectivity, but only at 1-hour post-mouthwash.
These results indicate that some of the mouthwashes currently used to reduce viral infectivity are not efficient and, furthermore, that this effect is not immediate, generating a false sense of security. ClinicalTrials.gov identifier: NCT04707742..
背景：研究表明，几种口腔消毒剂对 SARS-CoV-2 具有病毒杀灭活性。因此，漱口水已被提议作为一种易于实施的策略来降低病毒传播。然而，尚无测量使用漱口水后 SARS-CoV-2 存活能力的相关数据。
在这项随机、双盲、五组平行、安慰剂对照的临床试验中，在 54 名 COVID-19 患者中，评估了四种不同的口腔消毒剂和安慰剂漱口前后唾液中的 SARS-CoV-2 病毒载量（通过定量 PCR 检测）及其感染能力（将唾液孵育在细胞培养物中）。
与证据相反，四种测试的漱口水均未影响唾液中的病毒载量。病毒培养表明，氯化十六烷基吡啶（CPC）显著降低了病毒的感染力，但仅在漱口后 1 小时内有效。
这些结果表明，目前用于降低病毒感染力的一些漱口水并不有效，而且，这种效果不是即时的，会产生一种虚假的安全感。临床试验注册号：NCT04707742。
