Department of Translational Medicine, Maggiore Della Carità University Hospital, University of Eastern Piedmont, Via Solaroli 17, 28100, Novara, Italy.
Division of General Surgery, Department of Health Sciences, Maggiore Della Carità University Hospital, University of Eastern Piedmont, Via Solaroli 17, 28100, Novara, Italy.
Dig Dis Sci. 2023 Mar;68(3):913-921. doi: 10.1007/s10620-022-07600-x. Epub 2022 Jul 7.
Growing evidence supports the role of the intestinal microbiome in the development of different intestinal and extraintestinal diseases. Diverticular disease (DD) is one of the most common disorders in western countries. In the last years, different articles have suggested a possible role of the intestinal microbiome in DD pathogenesis and in the development of acute diverticulitis (AD). This systematic review aimed to clarify the current knowledge on the role of the intestinal microbiome in colonic diverticulitis in different stages according to the 2009 PRISMA guidelines.
Two independent reviewers searched the literature in a systematic manner through online databases, including Medline, Scopus, Embase, Cochrane Oral Health Group Specialized Register, ProQuest Dissertations and Theses Database, and Google Scholar. Patients with any stage of disease were included. The Newcastle-Ottawa scale for case-control and cohort studies was used for the quality assessment of the selected articles.
Overall, nine studies were included in the review. Only one article was focused on patients with AD, while all other articles only considered patients with DD without acute inflammation signs. Enterobacteriaceae seems to be the microbiota most associated with the disease, followed by Bifidobacteria.
All the included studies showed great heterogeneity in population characteristics and sampling methods. Therefore, given the high prevalence of colonic diverticulitis in the general population, further studies are needed to clarify the role of the intestinal microbiome, paving the way to new target therapies with important social implications.
越来越多的证据支持肠道微生物群在不同的肠道和肠道外疾病发展中的作用。憩室病（DD）是西方国家最常见的疾病之一。近年来，不同的文章表明，肠道微生物群可能在 DD 的发病机制以及急性憩室炎（AD）的发展中发挥作用。本系统评价旨在根据 2009 年 PRISMA 指南阐明肠道微生物群在不同阶段结肠憩室炎中的作用的现有知识。
两名独立审查员通过在线数据库（包括 Medline、Scopus、Embase、Cochrane 口腔健康组专业登记处、ProQuest Dissertations 和 Theses Database 以及 Google Scholar）系统地搜索文献。纳入任何疾病阶段的患者。使用纽卡斯尔-渥太华量表对选定文章进行病例对照和队列研究的质量评估。
总体而言，该综述纳入了 9 项研究。只有一篇文章专门针对 AD 患者，而其他所有文章仅考虑了没有急性炎症迹象的 DD 患者。肠杆菌科似乎是与该疾病最相关的微生物群，其次是双歧杆菌。
所有纳入的研究在人群特征和采样方法上都存在很大的异质性。因此，鉴于结肠憩室炎在普通人群中的高患病率，需要进一步研究以阐明肠道微生物群的作用，为具有重要社会意义的新靶向治疗铺平道路。
