Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.
Centre for Inflammation, Centenary Institute and University of Technology Sydney, School of Life Sciences, Faculty of Science, Sydney, NSW, 2007, Australia.
Environ Sci Pollut Res Int. 2022 Sep;29(42):62733-62754. doi: 10.1007/s11356-022-21454-w. Epub 2022 Jul 7.
Asthma is a chronic inflammatory disease primarily characterized by inflammation and reversible bronchoconstriction. It is currently one of the leading causes of morbidity and mortality in the world. Oxidative stress further complicates the pathology of the disease. The current treatment strategies for asthma mainly involve the use of anti-inflammatory agents and bronchodilators. However, long-term usage of such medications is associated with severe adverse effects and complications. Hence, there is an urgent need to develop newer, novel, and safe treatment modalities for the management of asthma. This has therefore prompted further investigations and detailed research to identify and develop novel therapeutic interventions from potent untapped resources. This review focuses on the significance of oxidative stressors that are primarily derived from both mitochondrial and non-mitochondrial sources in initiating the clinical features of asthma. The review also discusses the biological scavenging system of the body and factors that may lead to its malfunction which could result in altered states. Furthermore, the review provides a detailed insight into the therapeutic role of nutraceuticals as an effective strategy to attenuate the deleterious effects of oxidative stress and may be used in the mitigation of the cardinal features of bronchial asthma.
哮喘是一种慢性炎症性疾病，主要特征为炎症和可逆转的支气管收缩。它是目前全球发病率和死亡率的主要原因之一。氧化应激进一步使疾病的病理复杂化。目前哮喘的治疗策略主要涉及使用抗炎药和支气管扩张剂。然而，长期使用这些药物会引起严重的不良反应和并发症。因此，迫切需要开发新的、新颖的、安全的治疗方法来管理哮喘。这促使人们进一步进行研究和详细的研究，以确定和开发来自潜在资源的新型治疗干预措施。本综述重点介绍了主要来自线粒体和非线粒体来源的氧化应激源在引发哮喘临床特征中的重要性。该综述还讨论了身体的生物清除系统以及可能导致其功能障碍的因素，这可能导致状态改变。此外，该综述详细介绍了营养保健品的治疗作用，作为减轻氧化应激有害影响的有效策略，并可用于减轻支气管哮喘的主要特征。
