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纳米营养保健品对抗氧化应激:在辅助治疗中开辟新范式。

Nano-nutraceuticals to Combat Oxidative Stress: Unlocking Newer Paradigms in Adjuvant Therapy.

机构信息

Department of Pharmaceutical Sciences, Central University of Haryana, Mahendergarh, 123031, India.

Department of Pharmaceutics, Amity Institute of Pharmacy, Amity University, Noida, India.

出版信息

Curr Top Med Chem. 2024;24(17):1490-1503. doi: 10.2174/0115680266300779240417104340.

Abstract

Nutraceuticals are products that provide both nutritional and therapeutic benefits. These compounds can slow the aging process and provide physiological effects shielding individuals from acute and chronic diseases. People's interests have shifted from allopathic to Ayurvedic to nutraceuticals in recent years. These are often common dietary supplements that have drawn customers worldwide because of their high nutritional safety and lack of adverse effects when used for a long time. Although conventional dosage forms, including pills, tablets, and semi-solids, are still available, they nevertheless have poorer bioavailability, less stability, and less effectiveness for targeted delivery of bioactives. The use of effective nanocomplex systems as nano-antioxidants using nanotechnology has become a promising field. Among its many uses, nanotechnology is mostly used to create foods and nutraceuticals that are more bioavailable, less toxic, and more sustainable. Additionally, it has been emphasized how precisely nano-pharmaceuticals for oxidative stress produce the desired effects. These improvements show improved antioxidant delivery to the target region, reduced leakage, and increased targeting precision. The outcomes demonstrated that oxidative stress-related illnesses can be effectively treated by lowering ROS levels with the use of nanonutraceuticals. The major ideas and uses of nano-nutraceuticals for health are outlined in this review, with an emphasis on reducing oxidative stress.

摘要

营养保健品既提供营养又具有治疗功效。这些化合物可以减缓衰老过程,并提供生理效应,使个体免受急性和慢性疾病的影响。近年来,人们的兴趣已经从对抗疗法转移到顺势疗法再到营养保健品。这些营养保健品通常是常见的膳食补充剂,由于其高营养安全性和长期使用无不良反应,吸引了全球客户。尽管传统的剂型,包括药丸、片剂和半固体,仍然可用,但它们的生物利用度较差,稳定性较低,对生物活性物质的靶向递送效果也较差。利用纳米技术作为纳米抗氧化剂的有效纳米复合系统已成为一个有前途的领域。纳米技术在许多用途中,主要用于创造更具生物利用度、毒性更低、更可持续的食品和营养保健品。此外,还强调了纳米药物如何精确地产生抗氧化应激的所需效果。这些改进表明,通过使用纳米营养保健品将抗氧化剂递送到目标区域,可以提高抗氧化剂的递送效果,减少泄漏,并提高靶向精度。研究结果表明,使用纳米营养保健品降低 ROS 水平可以有效治疗与氧化应激相关的疾病。本综述重点介绍了纳米营养保健品在健康方面的主要思路和用途,特别是在降低氧化应激方面。

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