Liu Weiwei, Semcheddine Farouk, Jiang Hui, Wang Xuemei
State Key Laboratory of Bioelectronics, National Demonstration Center for Experimental Biomedical Engineering Education, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China.
School of Chemistry and Chemical Engineering, Southeast University, Nanjing 210096, China.
Bioconjug Chem. 2022 Jul 20;33(7):1405-1414. doi: 10.1021/acs.bioconjchem.2c00246. Epub 2022 Jul 7.
Camptothecin (CPT), a broad-spectrum anticancer drug, has been extensively used clinically. However, its hydrophobic properties seriously hinder its antitumor therapeutic effect. Herein, we synthesized acid-degradable FeO@poly(vinylpyrrolidone) (FeO@PVP)/gold nanoclusters@zeolitic imidazolate framework-8 composite nanoparticles (ZIF-8CNPs) via a facile method and utilized them as carriers to efficiently load CPT. The excellent fluorescence properties of gold nanoclusters (AuNCs) and the photothermal properties of FeO@poly(vinylpyrrolidone) (FeO@PVP) endowed the nanocomposites with excellent cell imaging and photothermal functions. In addition, the surface modification of the composite nanoparticles with folic acid-grafted bovine serum albumin (FA-BSA) enables them to efficiently target tumor cells. Once FA-BSA/ZIF-8CNPs-CPT are taken up by tumor cells and irradiated with a near-infrared laser, the nanoparticles show a highly effective inhibitory effect against various tumor cells through a chemo-photothermal synergistic effect. Hence, it is conceivable that this acid-responsive multifunctional ZIF-8 nanocomposite has promising bioapplication prospects in cancer treatment.
喜树碱（CPT）是一种广谱抗癌药物，已在临床上广泛应用。然而，其疏水性严重阻碍了其抗肿瘤治疗效果。在此，我们通过一种简便的方法合成了酸可降解的FeO@聚（乙烯基吡咯烷酮）（FeO@PVP）/金纳米簇@沸石咪唑酯骨架-8复合纳米粒子（ZIF-8CNPs），并将其用作载体以高效负载CPT。金纳米簇（AuNCs）的优异荧光特性和FeO@聚（乙烯基吡咯烷酮）（FeO@PVP）的光热特性赋予了纳米复合材料优异的细胞成像和光热功能。此外，用叶酸接枝的牛血清白蛋白（FA-BSA）对复合纳米粒子进行表面修饰，使其能够有效地靶向肿瘤细胞。一旦FA-BSA/ZIF-8CNPs-CPT被肿瘤细胞摄取并用近红外激光照射，纳米粒子通过化学-光热协同效应显示出对各种肿瘤细胞的高效抑制作用。因此，可以想象这种酸响应多功能ZIF-8纳米复合材料在癌症治疗中具有广阔的生物应用前景
