Department of Gastrointestinal Surgery, Ningbo Medical Center Lihuili Hospital (The Lihuili Affiliated Hospital, Ningbo University), Ningbo, Zhejiang, 315000, China.
Department of Gastroenterology, Ningbo First Hospital, Ningbo, Zhejiang, 315000, China.
Cancer Lett. 2022 Sep 28;544:215815. doi: 10.1016/j.canlet.2022.215815. Epub 2022 Jul 5.
N-methyladenosine (m6A) is a eukaryotic post-transcriptional modification involved in cell growth and developmental processes, including RNA transcription, alternative splicing, degradation, and translation. It is also involved in the development of various cancers. Metabolic reprogramming enables cancer cells to obtain nutrition from the tumor microenvironment, which is a hallmark of cancer. Numerous studies have shown that m6A modification induces metabolic reprogramming in cancer by regulating the expression of metabolic core genes or activation of metabolic signaling pathways. Digestive system malignancies include esophageal, gastric, colorectal, liver, pancreatic, and other cancers, all of which are associated with poor outcomes. This review summarizes the role of m6A modification in the metabolic reprogramming of digestive system malignancies, with the aim of identifying therapeutic strategies.
N6-甲基腺苷（m6A）是一种真核后转录修饰，参与细胞生长和发育过程，包括 RNA 转录、可变剪接、降解和翻译。它也参与各种癌症的发展。代谢重编程使癌细胞能够从肿瘤微环境中获取营养，这是癌症的一个标志。大量研究表明，m6A 修饰通过调节代谢核心基因的表达或激活代谢信号通路来诱导癌症的代谢重编程。消化系统恶性肿瘤包括食管癌、胃癌、结直肠癌、肝癌、胰腺癌等，均与不良预后相关。本文总结了 m6A 修饰在消化系统恶性肿瘤代谢重编程中的作用，旨在寻找治疗策略。
