Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Institute of Aging Research, School of Medical Technology, Guangdong Medical University, Songshan Lake, Dongguan 523808, China.
Biomolecules. 2023 Feb 1;13(2):273. doi: 10.3390/biom13020273.
The highly conserved and dynamically reversible N6-methyladenine (m6A) modification has emerged as a critical gene expression regulator by affecting RNA splicing, translation efficiency, and stability at the post-transcriptional level, which has been established to be involved in various physiological and pathological processes, including glycolipid metabolism and the development of glycolipid metabolic disease (GLMD). Hence, accumulating studies have focused on the effects and regulatory mechanisms of m6A modification on glucose metabolism, lipid metabolism, and GLMD. This review summarizes the underlying mechanism of how m6A modification regulates glucose and lipid metabolism-related enzymes, transcription factors, and signaling pathways and the advances of m6A regulatory mechanisms in GLMD in order to deepen the understanding of the association of m6A modification with glycolipid metabolism and GLMD.
高度保守且动态可逆的 N6-甲基腺嘌呤（m6A）修饰已成为一种关键的基因表达调控因子，通过影响 RNA 剪接、翻译效率和转录后水平的稳定性，参与了各种生理和病理过程，包括糖脂代谢和糖脂代谢疾病（GLMD）的发生。因此，越来越多的研究集中在 m6A 修饰对葡萄糖代谢、脂代谢和 GLMD 的影响及其调控机制上。本综述总结了 m6A 修饰调节葡萄糖和脂质代谢相关酶、转录因子和信号通路的潜在机制，以及 m6A 调控机制在 GLMD 中的研究进展，以期加深对 m6A 修饰与糖脂代谢和 GLMD 关联的理解。
