Li Yuanqi, Huang Hao, Wu Shaoxian, Zhou You, Huang Tao, Jiang Jingting
Tumor Biological Diagnosis and Treatment Center, The Third Affiliated Hospital of Soochow University, Changzhou 213003, China.
Jiangsu Engineering Research Center for Tumor Immunotherapy, Changzhou 213003, China.
Curr Gene Ther. 2023;23(1):51-59. doi: 10.2174/1566523222666220830150446.
As one of the main characteristics of neoplasia, metabolic reprogramming provides nutrition and energy to enhance cell proliferation and maintain environment homeostasis. Glycolysis is one of the most important components of cancer metabolism and the Warburg effect contributes to the competitive advantages of cancer cells in the threatened microenvironment. Studies show strong links between N-methyladenosine (mA) modification and metabolic recombination of cancer cells. As the most abundant modification in eukaryotic RNA, mA methylation plays important roles in regulating RNA processing, including splicing, stability, transportation, translation and degradation. The aberration of mA modification can be observed in a variety of diseases such as diabetes, neurological diseases and cancers. This review describes the mechanisms of mA on cancer glycolysis and their applications in cancer therapy and prognosis evaluation, aiming to emphasize the importance of targeting mA in modulating cancer metabolism.
作为肿瘤形成的主要特征之一，代谢重编程为细胞增殖提供营养和能量，以维持环境稳态。糖酵解是癌症代谢的最重要组成部分之一，而瓦伯格效应有助于癌细胞在受到威胁的微环境中获得竞争优势。研究表明，N-甲基腺苷（mA）修饰与癌细胞的代谢重组之间存在密切联系。作为真核RNA中最丰富的修饰，mA甲基化在调节RNA加工过程中发挥重要作用，包括剪接、稳定性、运输、翻译和降解。在糖尿病、神经疾病和癌症等多种疾病中均可观察到mA修饰的异常。本综述描述了mA对癌症糖酵解的作用机制及其在癌症治疗和预后评估中的应用，旨在强调靶向mA调节癌症代谢的重要性。
