Pharmacokinetics of Bevidox in functionally different muscles of albino rat during prolonged intense activity.

Intramuscular Bevidox treatment for five days influenced the metabolic status and functional efficiency of the different types of muscles in rat during exhaustion. Glycogen and protein depletion observed during exhaustion was alleviated by Bevidox treatment to a greater extent in cardiac and soleus over the other muscles. The improved metabolic function of the muscles during contractile stress has been related to stepped up energy cycle operations through increased transamination reactions and consequent feeding of glycogenic and ketogenic amino acids into oxidative pathway besides, rapid supply of glucose moieties by stimulated phosphorylase action on vitamin treatment.