Gryglewski R J, Korbut R, Ocetkiewicz A, Spławiński J, Wojtaszek B, Swies J
Naunyn Schmiedebergs Arch Pharmacol. 1978 Aug;304(1):45-50. doi: 10.1007/BF00501376.
In vivo anti-platelet de-aggregatory activity of exogenous prostacyclin is enhanced after its passage through the pulmonary circulation of anaesthetized cats, probably because of a concomitant generation of endogenous prostacyclin by the lungs. Evidence is also presented that perfused lungs of guinea pigs and rats spontaneously release considerable amounts of prostacyclin. It is therefore postulated that a continuous biosynthesis of prostacyclin by pulmonary endothelium is a general physiological phenomenon, while the generation of thromboxane A2 by lungs occurs in response to pathological stimuli. Coronary and cerebral arteries are supposed to benefit from this hormonal function of the lungs.
外源性前列环素在经过麻醉猫的肺循环后，其体内抗血小板解聚活性增强，这可能是因为肺同时产生了内源性前列环素。还有证据表明，豚鼠和大鼠的灌注肺会自发释放大量前列环素。因此推测，肺内皮细胞持续生物合成前列环素是一种普遍的生理现象，而肺产生血栓素A2是对病理刺激的反应。冠状动脉和脑动脉被认为受益于肺的这种激素功能。
