伊朗北部马赞德兰省血液透析患者中乙肝和丙肝病毒感染及免疫情况

Prevalence of hepatitis B and C virus infections and immunity among hemodialysis patients in the Mazandaran province, Northern Iran.

作者信息

Darrudi Amin, Nava Melody Omrani, Ebrahimi Ata, Ghaffari Kosar, Moghaddam Kasra Ahmadi, Roozbeh Fatemeh

机构信息

Infectious Disease Department, Sari Branch, Islamic Azad University, Sari, Iran.

Student Research Committee, Sari Branch, Islamic Azad University, Sari, Iran.

出版信息

J Family Med Prim Care. 2022 May;11(5):1785-1788. doi: 10.4103/jfmpc.jfmpc_1261_21. Epub 2022 May 14.

DOI:10.4103/jfmpc.jfmpc_1261_21

PMID:35800504

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9254791/

Abstract

BACKGROUND

Hemodialysis (HD) is one of the most common causes of blood-borne infections. In order to prevent viral hepatitis and confront with the virus on the next step, health providers specify infected patients by screening and vaccination. This study is designed to investigate the prevalence of Hepatitis B virus (HBV) and Hepatitis C virus (HCV) infections in HD patients in Mazandaran, Iran.

METHODS

The medical records of 216 patients referred to the hemodialysis centers were evaluated in this cross-sectional study between 2019 and 2020. The collected data was analyzed using -test and Chi-square.

RESULTS

Among 216 patients, 106 cases were female (49.07%) and 110 subjects were male (50.9%). The mean age was 40.1 y/o in females and 50.9 y/o in the male patients. The study recorded nine HBs-Ag positive (prevalence: 0.06%) and 15 HCV-Ab positive (prevalence: 6.94%) patients. Also, the most common co-morbidities were diabetes and hypertension. It was observed that 13 patients from 34 patients with negative HBs-Ag (who had 10-100 U HBs-Ab in the first stage) experienced sudden drop in the antibody titration to less than 10 U ( < 0.05). From 50 HBs-Ag negative patients with HBs-Ab more than 100 U in the first stage, antibody titration of five patients was decreased to less than 10 U in the second stage ( < 0.05).

CONCLUSIONS

The prevalence of HCV and HBV was low in HD patients in Mazandaran province. However, due to the large number of patients with non-protective HBs-Ab levels, there is a risk of an increased prevalence of the disease.

摘要

背景

血液透析（HD）是血源性感染最常见的原因之一。为预防病毒性肝炎并在后续应对病毒，医疗服务提供者通过筛查和接种疫苗来确定感染患者。本研究旨在调查伊朗马赞德兰省血液透析患者中乙型肝炎病毒（HBV）和丙型肝炎病毒（HCV）感染的患病率。

方法

在这项2019年至2020年的横断面研究中，对转诊至血液透析中心的216例患者的病历进行了评估。使用t检验和卡方检验对收集的数据进行分析。

结果

216例患者中，106例为女性（49.07%），110例为男性（50.9%）。女性患者的平均年龄为40.1岁，男性患者为50.9岁。该研究记录了9例HBs-Ag阳性患者（患病率：0.06%）和15例HCV-Ab阳性患者（患病率：6.94%）。此外，最常见的合并症是糖尿病和高血压。观察到，在34例HBs-Ag阴性患者（第一阶段HBs-Ab为10 - 100 U）中，有13例患者的抗体滴度突然降至低于10 U（P < 0.05）。在第一阶段HBs-Ab超过100 U的50例HBs-Ag阴性患者中，有5例患者的抗体滴度在第二阶段降至低于10 U（P < 0.05）。