Miles Brittany, Bazuaye-Ekwuyasi Eseosa A, Mallick Jayati, Nguyen Quan D
Medical Education, University of Texas Medical Branch, Galveston, USA.
Radiology, University of Texas Medical Branch, Galveston, USA.
Cureus. 2022 May 31;14(5):e25526. doi: 10.7759/cureus.25526. eCollection 2022 May.
Previously believed to be an exaggerated immune response and not a lymphoma, angioimmunoblastic T-cell lymphoma (AITL) is now recognized as a rare variant of peripheral T-cell lymphoma with an aggressive clinical course and poor response to current therapies. There is no standard of care for treatment, but the identification of extranodal involvement is useful for prognostic purposes since the involvement of more than one extranodal site can escalate the patient's risk category on the International Prognostic Index (IPI). Here we present the case of a patient with AITL who initially presented with an extranodal disease in the form of a fluorodeoxyglucose (FDG)-avid subcutaneous nodule and probable involvement of the spleen. After two months of treatment, her lymphoma exhibited an escalation of grade and an extensive worsening of Epstein-Barr virus (EBV) positivity.
血管免疫母细胞性T细胞淋巴瘤（AITL）曾被认为是一种过度的免疫反应而非淋巴瘤，现在被公认为外周T细胞淋巴瘤的一种罕见变体，临床病程侵袭性强，对当前治疗反应不佳。目前尚无标准的治疗方案，但识别结外受累情况对预后评估有帮助，因为国际预后指数（IPI）显示，结外受累部位超过一处会使患者的风险类别升高。在此，我们报告一例AITL患者，该患者最初以氟脱氧葡萄糖（FDG）摄取阳性的皮下结节形式出现结外疾病，脾脏可能受累。经过两个月的治疗，她的淋巴瘤分级升高，爱泼斯坦-巴尔病毒（EBV）阳性情况广泛恶化。
